Vergleich: Siehe: Fabales
[Clifford J. Bailey]
Metformin (dimethylbiguanide/Quelle remedia.at) has become the preferred
first-line oral blood glucose-lowering agent to manage type 2 diabetes.
Its history is linked
to Galega officinalis (= goat’s rue), a traditional herbal medicine in
Europe, found to be rich in guanidine, which, in 1918, was shown to lower blood
glucose. Guanidine derivatives, incl. metformin, were synthesised and some (not
metformin) were used to treat diabetes in the 1920s and 1930s but were
discontinued due to toxicity and the increased availability of insulin.
Metformin was rediscovered in the search for antimalarial agents in the 1940s and,
during clinical tests, proved useful to treat influenza
when it sometimes lowered blood glucose. This property was pursued by
the French physician Jean Sterne, who first reported the use of metformin to
treat diabetes in 1957.
Repertorium:
Magen: Appetit fehlend
Nieren: Schmerz (Wehtun)
Urin: Spärlich
Brust: Entzündete Mammae
Rücken: Schmerz
Allgemeines: Diabetes mellitus
Beschwerden während Laktation
Schwäche
Phytologie: Frühstadium Diabetes/harntreibend/Aufguss/fördert
Milch
Vorwort/Suchen Zeichen/Abkürzungen Impressum