Krebs Anhang 2
18/12/2011
Prostate cancer + Pomegranate
"In
conclusion, these studies reveal novel interactions between the IGF system and
pomegranate-induced apoptosis, and suggest that pomegranate products modulate the
tumor production and responsiveness to IGFs and the IGFBPs. As IGFBP-3 is
currently being tested in humans as a treatment for prostate cancer and
pomegranate supplements are becoming popular as adjuvant nutritional treatments
for this disease, we propose that these agents
may emerge
as useful in the management of prostate cancer“.
Pomegranate
extract inhibits androgen-independent prostate cancer growth through a nuclear
factor-κB-dependent
mechanism
"Extending
the duration of the androgen-dependent state could potentially prolong life
expectancy of prostate cancer patients and delay or prevent the need for
additional hormonal therapy or chemotherapy. In this regard, our finding that
PE delayed the growth and emergence of androgen independence in our xenograft
model may be particularly germane. Of importance, our group showed previously
that dietary fat reduction delayed the emergence
of androgen
independence and prolonged survival using a similar xenograft model (36).
Future research will focus on potential additive and/or synergistic effects of
combining a low-fat diet with PE. Based on our results, we propose that PJ
could have potential as a dietary agent to prevent the emergence of androgen
independence and suggest that this may be a high priority area for future
clinical investigation"
Colon cancer + Chinese Red Yeast Rice = red
fermented rice, red kojic rice, red koji rice, anka, or ang-kak, is a bright
reddish purple fermented rice, which acquires its colour from being cultivated
with the mold
Monascus
purpureus. "RYR, a traditional Chinese food herb and a modern dietary
supplement, has demonstrated in vitro effects including inhibition of
proliferation and stimulation of apoptosis in human colon cancer cells by
mechanisms involving MK and the red yeast pigment fraction"
Ovarian, Cervical, Breast,
Phytochemicals,
antioxidant properties and anticancer investigations of the different parts of
several gingers species (Boesenbergia rotunda, Boesenbergia pulchella var
attenuata and Boesenbergia armeniaca)
"In
the cytotoxicity assay, B. rotunda showed the most prominent and promising
result as anticancer medicinal plant. It showed positive antiproliferative
effect against five cancer cell lines: ovarian (CaOV3), breast
(MDA-MB-231
and MCF-7), cervical (HeLa) and colon (HT-29) cancer cell lines with 3-(4,
5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay conducted.
In addition, the rhizome of B. pulchella var
attenuata
and B. armeniaca shown positive result in cytotoxicity assay tested against
breast cancer (MCF-7). Thus, the Boesenbergia species investigated would be a
promising anticancer remedy for breast cancer“.
Cancer Prevention + Nutrition
"Recent
evidence suggests that nutrients and other bioactive food components protect
against cancer through modulation of miRNA expression. Moreover, dietary
factors have been shown to modify miRNA expression and
their mRNA
targets in various cancer processes, including apoptosis, cell cycle
regulation, differentiation, inflammation, angiogenesis, and metastasis as well
as pathways in stress response. Herein, we provide a brief
overview of
dietary modulation of miRNA expression and its potential role in cancer
prevention. Understanding the affect of dietary factors on miRNA expression and
function may provide insight on prevention strategies to reduce the burden of
cancer“.
Cancer general + Vitamin C
Vitamin C:
A Concentration-Function Approach Yields Pharmacology and Therapeutic
Discoveries
"Pharmacologic
ascorbate can elicit cytotoxicity toward cancer cells and slow the growth of
tumors in experimental murine models. The effects of pharmacologic ascorbate
should be further studied in diseases, such as cancer
and
infections, which may respond to generation of reactive oxygen species via
H2O2“.
Cancer general + European Mistletoe
Survival of
cancer patients treated with mistletoe extract (Iscador): a systematic
literature review.
"Pooled
analysis of clinical studies suggests that adjuvant treatment of cancer
patients with the mistletoe extract Iscador is associated with a better
survival. Despite obvious limitations, and strong hints for a publication bias
which
limits the evidence found in this meta-analysis, one can not ignore the fact
that studies with positive effects of VA-E on survival of cancer patients are
accumulating"
Rectum,
Use of
Iscador an extract of European Mistletoe (Viscum Album), in Cancer Treatment:
Prospective Nonrandomized and Randomized Matched-Pair Studies Nested Within A
Cohorot Study
"Mistletoe
extracts, which contain a complex of oncologically relevant active substances
andexert a variety of anticancer effects, appear to prolong survival times in
patients with various tumor types. In the studies described here, efficacy was
observed in patients with rectum carcinoma, colon carcinoma, stomach carcinoma,
breast carcinoma (with or without axillary metastases or remote metastases),
and small cell and non-small-cell bronchogenic carcinoma. The study findings support
the claim of anthroposophical medicine that mistletoe therapy is generally
effective for treating cancer, irrespective of tumor type“.
Anticancer Drugs + DHA + Improved Efficacy
Docosahexaenoic
acid: A natural powerful adjuvant that improves efficacy for anticancer
treatment with no adverse effects.
"The
data suggest that DHA is a safe, natural compound that can greatly improve the
anticancer properties of anticancer drugs. Use of DHA with anticancer
treatments provides an avenue to therapeutic improvement that
involves
less risk or side effects for patients and reduced regulatory burden for
implementation“.
There are
two major types of omega-3 fatty acids in our diets: One type is
alpha-linolenic acid (
and in
walnuts.
Lung cancer + Silybum marianum / St. Mary's
Thistle
Silibinin
modulates TNF-α
and IFN-γ mediated
signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung
epithelial LM2 cells
"Together,
we showed that STAT3 and STAT1 could be valuable chemopreventive and
therapeutic targets within the lung tumor microenvironment in addition to being
targets within tumor itself, and that silibinin inhibits their activation as a
plausible mechanism of its efficacy against lung cancer"
NB
Silibinin (INN), also known as silybin, is the major active constituent of
silymarin, standardized extract of the milk thistle seeds (Silybum marianum)
Melanoma + Radiotherapy + Survival + Withania
somnifera / Ashwaghanda
Enhancement
of the Response of B16F1 Melanoma to Fractionated Radiotherapy and Prolongation
of Survival
by Withaferin A and/or Hyperthermia
" In
conclusion, WA is a better radiosensitizer than HT in fractionated regimen and
the response of radioresistant tumors like melanoma can be significantly
enhanced by combining nontoxic doses of WA with fractionated RT, with or
without HT, allowing decrease in radiation dose“.
Spirituality + cancer
Positive
Changes, Increased Spiritual Importance, and Complementary and Alternative
Medicine (
"our
study offers important insights into the spiritual experience following cancer
among a large sample of survivors with different tumor types. Positive changes
are common among survivors, even among those living with cancer...The strong
relationship between
Bojungikki-Tang (= a Chinese classic herbal
formula) + Cancer-related fatigue
Bojungikki-Tang
for Cancer-Related Fatigue: A Pilot Randomized Clinical Trial
"Despite
its limitations, we believe that our study reports interesting data on the
potentials of Bojungikki-tang to be used for cancer-related fatigue and to
improve quality of life in cancer patients"
Glioblastoma + Cannabidiols
Cannabidiol
Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell
Proliferation and Survival
"The
treatment of glioblastoma cells with both compounds led to significant
modulations of the cell cycle and induction of reactive oxygen species and
apoptosis as well as specific modulations of extracellular signal-regulated
kinase and caspase activities. These specific changes were not observed with
either compound individually, indicating that the signal transduction pathways
affected by the combination treatment were unique. Our results suggest that the
addition of cannabidiol to Δ9-THC may improve the overall effectiveness of Δ9-THC in the treatment of
glioblastoma in cancer patients“.
Cancer general + Calcitriol (active form of
Vitamin D)
Calcitriol
in cancer treatment: From the lab to the clinic
"1,25-Dihydroxyvitamin
D (calcitriol), the most active metabolite of vitamin D, has significant
antineoplastic activity in preclinical models. Several mechanisms of activity
have been proposed. These include inhibition of proliferation associated with
cell cycle arrest and, in some models, differentiation, reduction in
invasiveness and angiogenesis, and induction of apoptosis. Proposed mechanisms
differ between tumor models and experimental conditions, and no unifying
hypothesis about the mechanism of antineoplastic activity has emerged.....Further
work is needed to elucidate the molecular mechanisms of antineoplastic activity
and optimal clinical applications of calcitriol in cancer. "
NB-Calcitriol
also called 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3, is the
hormonally active form of vitamin D
Esophageal cancer, colorectal cancer and
hepatoma and Archidendron lucidum (Benth.)
Anti-tumor
effect of Archidendron lucidum (Benth.) against esophageal cancer, colorectal
cancer and hepatoma
"Our
results indicate that optimal dose of MEAL might possess the anti-tumor effects
against esophageal, hepatocellular and colorectal cancers with a relative
safety profile. Accordingly, we are purifying effective and less toxic
compounds from MEAL“.
Renal cancer + Guan-Jen-Huang (Aeginetia indica Linn.)
Effects of
a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal
Cancer Cell Growth and Metastasis
"These
results suggest that GJH extract has a synergistic effect on apoptosis induced
by chemotherapeutic agents and an inhibitory effect on cell adhesion,
migration, and invasion, providing evidence for the use of water-based extracts
of GJH as novel alternative therapeutic agents in the treatment of human renal
cancer“.
Leukemias, lymphomas, multiple myeloma, brain
cancer, melanoma and skin, lung, prostate, breast, ovarian, liver,
gastrointestinal, pancreatic and colorectal epithelial cancers + Curcumin
Potential
applications of curcumin and its novel synthetic analogs and nanotechnology-based
formulations in cancer prevention and therapy
"Curcumin
has attracted great attention in the therapeutic arsenal in clinical oncology
due to its chemopreventive, antitumoral, radiosensibilizing and
chemosensibilizing activities against various types of aggressive and recurrent
cancers. These malignancies include leukemias, lymphomas, multiple myeloma,
brain cancer, melanoma and skin, lung, prostate, breast, ovarian, liver,
gastrointestinal, pancreatic and colorectal epithelial cancers. Curcumin
mediates its anti-proliferative, anti-invasive and apoptotic effects on cancer
cells, including cancer stem/progenitor cells and their progenies, through
multiple molecular mechanisms.
...Taken
together, these studies carried out in the last ten years have indicated that
curcumin may act on multiple oncogenic targets frequently deregulated in cancer
cells, including cancer stem/progenitor cells with stem cell-like properties,
during the progression of most human aggressive cancers"
Doxorubicin-induced Cardiotoxicity + Curcuma
longa
Cardioprotective
effects of Curcuma longa L. extracts against doxorubicin-induced cardiotoxicity
in rats
"Oral
administration of Curcuma longa ethanolic or water extract (200 mg/kg) prior to
doxorubicin produced a significant protection which was evidenced by
significant reduction in mortality, CK-MB and LDH -activities. Moreover, they
significantly increased GSH markedly, decreased cardiac calcium, and cardiac
and serum MDA. In addition, both extracts significantly reduced serum nitric
oxide, increased cardiac ascorbic acid, and ameliorated the antioxidant enzymes
activities. In conclusion, Curcuma longa extracts renders resiliency against
doxorubicin cardiotoxicity due to their contents of polyphenolic compounds that
might serve as novel adjuvant therapy with doxorubicin“.
Thoracic radiotherapy + Flaxseed
DIETARY
FLAXSEED PREVENTS RADIATION-INDUCED OXIDATIVE LUNG DAMAGE, INFLAMMATION AND
FIBROSIS IN A MOUSE MODEL OF THORACIC RADIATION INJURY
"In
summary, this study evaluates a non-toxic, widely available nutritional
supplement that offers long term radioprotective effects in the setting of
thoracic radiotherapy. Potential mechanisms of the effects of prolonged FS
feeding include altering immediate XRT-induced markers of lung damage, creating
a baseline radioprotective state prior to XRT, and providing high levels of
circulating antioxidants from the continued metabolism is of bioactive
lignans“.
Cancer general + Rhaphidophora korthalsii
Immunomodulatory
Effect of Rhaphidophora korthalsii on Natural Killer Cell Cytotoxicity
"In
this study, stimulation of the immune system by R. korthalsii methanol extract
had significant effects on proliferation, NK cell population, and cytokine
expression in the host, which further enhanced the cytolytic activity of the
immune cells. Up till now, 5,6-dihydroxyindole (DHI) is the only compound
successfully isolated from R. korthalsii. However, role of DHI on the
immunomodulatory effect of R. korthalsii methanol extract and the other
potential active secondary metabolites that play an important role in this
immunostimulatory effect are still unknown. Thus, future study should focus on
isolation and evaluation of active metabolites from the extract that
contributes to the immunomodulatory effect against the NK cell“.
Prostate cancer + Lycopene
Multitargeted
therapy of cancer by lycopene
"These
epidemiological studies are supported by numerous in vitro assays using cell
cultures that show anti-cancer activities and cancer chemoprevention activities
of lycopene in many cell lines including prostate cancer cells. These
activities include inducing apoptosis, inhibiting metastasis, preventing
oxidative stress, and up-regulating the antioxidant response element so that
cells can produce cytoprotective enzymes against prooxidants and electrophiles.
In vivo animal studies and Phase I and II clinical trials have shown that
lycopene supplements are non-toxic and that lycopene is orally bioavailable.
Furthermore, lycopene is concentrated in prostate tissue and localized to the
nucleus. In addition, some oxygenated metabolites of lycopene have been
identified, and might be active as chemoprevention agents“.
NB lycopene
is responsible for the red pigmentation of ripe tomatoes and some other edible
fruits such as watermelon and papaya.
Esophageal squamous cell carcinoma,gastric +
hepatoma + cervical cancer + Daphne Altaica
Antiproliferative
activity of different extracts from Daphne altaica Pall. on selected cancer
cells
"The
results of this study represent the first evidence that barks of D. altaica
possess effective antiproliferative activities on human cancer cells. Future
phytochemical investigations on this medicinal plant should be encouraged“.
Pancreatic, lung, liver, breast, ovarian cancer
+ more + metastasis + Pau D'Arco
Lapachol:
an overview
"Lapachol
is a naphthoquinone that was first isolated by E. Paterno from Tabebuia
avellanedae
(Bignoniaceae)
in 1882....many others confirmed the efficacy of this naphthoquinone as an
antineoplastic agent. However, in 1974, the National Cancer Institute concluded
that, due to the high concentrations necessary for this drug to act as an
effective chemotherapeutic agent in human cancer which unfortunately also
resulted in very toxic side effects, suspension of further studies on the
action of lapachol as an antineoplastic agent would be terminated. However,
none of these studies considered the effects of lapachol at a molecular level.
This information forms the basis to develop the synthesis of new and novel
lapachol analogues which can be used as the future starting point in future
developments of this potentially potent biological molecule“.
Leukemia +
Thymoquinone
rich fraction from Nigella sativa and thymoquinone are cytotoxic towards colon
and leukemic carcinoma cell lines
"In
conclusion, this study indicates that TQRF and TQ possess cytotoxic properties
against colorectal cancer and showed more prominent cytotoxic effects on
leukemic cell lines. In spite of TQ, TQRF was also has potential to be used as
anti-cancer treatment. Therefore, TQRF from N. sativa does have the potential
to be developed as a nutraceuticals for preventing the progression of cancer“.
Breast cancer and Tamoxifen and Fish Oil
The Impact
of Fish Oil on the Chemopreventive Efficacy of Tamoxifen against Development of
N-Methyl-N-Nitrosourea–Induced Rat Mammary Carcinogenesis
"In
this study, we report for the first time that the combination of a fish oil
diet rich in n-3 PUFA and tamoxifen seemed to inhibit N-methyl-N-nitrosourea–induced
mammary carcinogenesis, tumor multiplicity, and volume to a greater extent than
the individual interventions. The potential superiority of the combination was
particularly evident at a suboptimal dose of tamoxifen, which, by itself, was
unable to significantly decrease tumor development. Because activation of PPARγ is known to inhibit oxidative
stress, we examined the effects of our interventions on circulating and tumor
levels of glutathione, a major intracellular antioxidant. Our results indicate
that reduction in the level of oxidative stress may be a potential mechanism by
which the n-3 PUFA–rich diet potentiated the tumor-suppressive effect of
tamoxifen. Our interventions were well tolerated without evidence of toxicity.
Combined administration of tamoxifen and n-3 PUFA is a promising new approach
to breast cancer prevention. Because of its safety, this combination can
quickly be translated to the clinic if its superiority can be supported by
future studies“.
Skin cancer and Resveratrol
Synergistic
Effects of Combined Phytochemicals and Skin Cancer Prevention in SENCAR Mice
" In
conclusion, all combinations showed either additive or synergistic effects and
their joint actions allowed for decreasing the doses of the compounds.
Especially, resveratrol combinations with ellagic acid, grape seed extract, and
other phytochemicals are very potent inhibitors of skin tumorgenesis, based on
the suppression of epidermal hyperplasia as well as on the modulation of
intermediate biomarkers of cell proliferation, cell survival, inflammation,
oncogene mutation, and apoptosis“.
Resveratrol
is an antioxidant that is commonly found in many plants. Red wine, peanuts,
grapes and blueberries are some of its rich and popular sources.
Skin cancer + foods containing alkaloids
(caffeine), EGEC (green tea), flavanols (cocoa), genistein (soybean),
Pycnogenol and more
Phytochemicals
as Protectors Against Ultraviolet Radiation: Versatility of Effects and
Mechanisms
"Various
phytochemicals protect plants and animals against the damaging effects of UV
radiation. They all invoke multiple protective mechanisms, in many ways
representing a critical feature in the efforts to develop protective strategies
against a carcinogen that exerts multiple damaging effects. The use of agents
based on some of the phytochemicals that were discussed here and the
identification of new and more potent analogues, in addition to common
sunscreens, are areas of development that have the potential to reduce the risk
of skin cancer“.
Chemoprevention + foods containing curcumin
(turmeric) EGCG (green tea), resveratrol (red wine), genistein (soy) and
isothiocyanates(cabbage family)
Dietary
Cancer Chemopreventive Agents – Targeting Inflammation and Nrf2 Signaling
Pathway
dietary
vegetables and fruits have been regarded as rich sources of chemopreventive
agents.
Food
phytochemicals such as curcumin, EGCG, resveratrol, genistein and
isothiocyanates, with strong anti-inflammatory activity, have been shown to
inhibit carcinogenesis in preclinical animal models. Epidemiological studies
have clearly documented that the frequent consumption of a diet high in fruits
and vegetables has been linked to a lower risk of many types of cancers
including prostate, colon, oral cavity, stomach, lung and esophagus"
Chemoprevention + foods containing-sulforaphane
(cabbage), lycopene (tomatoes), curcumin (turmeric), EBCG (green tea) Diallyl
sulfide (garlic), Resveratrol (red grapes) and more
Nrf2 as a
Master Redox Switch in Turning on the Cellular Signaling Involved in the
Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals
"The
activation of Nrf2-ARE signaling by dietary inducers will fortify cellular
defense against oxidative, electrophilic and inflammatory stresses which are
broadly implicated in multi-stage carcinogenesis"
Colorectal cancer + Fresh Ginseng
Effects of
Triterpenoid Glycosides from Fresh Ginseng
"AGBE
and ginsenosides Rb3, Re, and Rg3 possessed significant antiproliferative
effects and induced changes of morphological appearance on SW480 cells. The
mechanisms of the antiproliferation of AGBE and tested ginsenosides involved
could be cell cycle arrest and induction of apoptosis“.
Cancer general + Dysosma versipellis
Antiproliferation
and cell apoptosis inducing bioactivities of constituents from Dysosma
versipellis in PC3 and Bcap-37 cell lines
"This
study suggests that most of the compounds from the roots of D. versipellis
could inhibit the growth of human carcinoma cells. In addition, PTO and DDPT
could induce apoptosis of tumor cells“.
Bladder cancer + Antrodia camphorate
Antrodia
camphorata extract induces replicative senescence in superficial TCC, and
inhibits the absolute migration capability in invasive bladder carcinoma cells
"We
conclude that ACCE can be rather effective and beneficial in suppression of
both the superficial cancer cell line RT4 and the metastatic cell lines
(TSGH-8301 and T24) through different mechanisms"
Inhibition
of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human
Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated
from the Fruiting Body of Antrodia camphorate
"These
findings demonstrate for the first time that SY-1 inhibits human colon cancer
cell proliferation through inhibition of cell growth and anchorage-independent
colony formation in soft agar. However, the detailed mechanisms of these
processes remain unclear and will require further investigation“.
Metastases + Liver cancer + Sea Cucumber
Ds-echinoside
A, a new triterpene glycoside derived from sea cucumber, exhibits
antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions
"In conclusion,
the present study provides evidence that DSEA possesses marked anti-metastatic
activity. We have shown that DSEA plays a role in the inhibition of Hep G2 cell
migration, invasion, and angiogenesis through suppression of VEGF and MMP-9 and
enhancement of TIMP-1 protein expression by blocking the NF-κB signaling pathway“.
Cancer Prevention + Spices
Potential
of Spice-Derived Phytochemicals for Cancer Prevention
"From
the description provided above it is clear that spice-derived phytochemicals
have an enormous potential in the prevention and treatment of cancer. They can
induce apoptosis, suppress proliferation of tumor cells, inhibit invasion and
angiogenesis, and prevent even bone loss. These phytochemicals mediate their
effects through multiple targets and yet pharmacologically they are highly
safe. More animal studies and clinical trials are needed to prove the
usefulness of these agents. Safety, inexpensive cost, years of intake by humans
and their efficacy make them ideal agents. Therefore it is not too surprising
to note that Vasco de Gama tried to look for these spices almost five centuries
ago“.
Breast + Pancreatic cancer + Amoora
rohituka and chittagonga
Cytotoxicity
Effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer
Cells
" For
MCF-7 cancer cells, the chittagonga (Pet-Ether and CH2Cl2) and rohituka
(Pet-Ether) extracts induced cytotoxicity; the chittagonga (EtoAC) and rohituka
(MeOH) extracts did not induce cytotoxicity. For HTB126, Panc-1, Mia-Paca2, and
Capan-1 cancer cells, only the chittagonga CH2Cl2 extract showed a significant
cytotoxic effect. The extracts were not cytotoxic to normal fibroblast Hs68
cells, which may be correlated to the specificity of Amoora extracts in
targeting cancerous cells. Based on these results, further examination of the
potential anticancer properties Amoora species and the identification of the
active ingredients of these extracts is warranted“.
Cancer-related Fatigue + Polarity Therapy
Polarity
Therapy for Cancer-Related Fatigue in Patients With Breast Cancer Receiving
Radiation Therapy: A Randomized Controlled Pilot Study
"The
present study supports previous experimental research showing that PT, a
noninvasive and gentle energy therapy, may be effective in controlling CRF. PT
is an integrative medicine energy therapy based on the Ayurvedic medical system
used for thousands of years in India and evidence of its efficacy could lead to
further, potentially fruitful, explorations of this ancient medical practice
and/or of other energy therapies such as HT, TT, and Reiki“.
Lung cancer + Essential Oils
Terpinen-4-ol
Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo"
"Collectively,
these data provide insight into the molecular mechanisms underlying
terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a
potential anticancer drug for NSCLC“.
Colorectal cancer + Sulforaphane (in
cruciferous vegetables)
Apoptosis
Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor
Growth in SCID Mice by Sulforaphane
"Our
findings suggest that, in addition to the known effects on cancer prevention,
sulforaphane may have antitumor activity in established colorectal cancer“.
Sulforaphane
(SFN), a potent cancer preventive agent, is a dietary isothiocyanate compound
found as a precursor glucosinolate in cruciferous vegetables such as Brussels
sprouts, cauliflower, and broccoli
Doxorubicin-Induced Cardiotoxicity +
L-Glutamine
Oral
Glutamine Protects against Acute Doxorubicin-Induced Cardiotoxicity of Tumor-Bearing
Rats
"The
Gln supplementation resulted in lower cardiac lipid peroxidation and
peroxintrite levels and elevated cardiac catalase enzyme activity and GSH
compared with the controls, without affecting those of the tumors. DOX-induced
alterations of the echocardiographic parameters were significantly reduced in
the Gln-supplemented rats. These data indicate that Gln is able to reduce the
oxidative damage of cardiomyocytes that occurs soon after DOX administration
and thus protects the heart of a tumor-bearing host from DOX-induced
cardiomyopathy“.
Breast cancer + Curcumin
Injectable
Sustained Release Microparticles of Curcumin: A New Concept for Cancer
Chemoprevention
The current
study is the first to report the use of an injectable, sustained release
formulation, which, after a single dose, results in near-constant systemic
concentrations of curcumin for several weeks and a significant inhibition of
tumor growth in an orthotopic mammary tumor model. Further, the results of the
study show that sustained low levels of curcumin achieved with microparticles
may elicit certain antitumor effects not observed after repeated systemic
injections.
Intrathoracic cancers + Radiation + Flaxseed
Dietary
flaxseed administered post thoracic
radiation treatment improves survival and
mitigates radiation-induced
pneumonopathy in mice
Dietary FS
given post-XRT mitigates radiation
effects by decreasing pulmonary fibrosis, inflammation, cytokine secretion and
lung damage while enhancing mouse survival. Dietary supplementation of FS may be a useful
adjuvant treatment mitigating adverse
effects of radiation in individuals exposed to inhaled radioisotopes or
incidental radiation.
Role of cyclin
inhibitor protein p21 in the inhibition of HCT116 human colon cancer cell
proliferation by American ginseng (Panax quinquefolius) and its constituents
"In
conclusion, the current study demonstrates that American ginseng extract inhibits proliferation and cell cycle
progression in HCT116 human colon cancer cells through altered expression of
key regulatory proteins, and these actions appear to be dependent on the
interaction of both ginsenoside and polysaccharide components of ginseng extract"
Prostate cancer + Psidium guajava
The Aqueous
Soluble Polyphenolic Fraction of Psidium guajava Leaves Exhibits Potent
Anti-Angiogenesis and Anti-Migration
Actions on DU145 Cells
"We
conclude that PE potentially possesses a strong anti-prostate cancer effect. Results
suggest that PE can be used as an effective clinical adjuvant anti-prostate
cancer chemopreventive"
Melanoma + Peganum harmala
Harmine
activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma
"TUNEL
assay and flow cytometric analysis also
confirmed apoptosis. Furthermore, RT-PCR
analysis showed that harmine induced
apoptosis in B16F-10 melanoma cells by
up-regulating Bax and activating Caspase-3, 9 and p53 and down-regulating
Bcl-2. Harmine also up-regulated
Caspase-8 and Bid, indicating that harmine affected both extrinsic and
intrinsic pathways of apoptosis. This
study also showed inhibitory effects of harmine on some transcription
factors and pro-inflammatory cytokines that protect cell from apoptosis"
Cancer Remission + Agaricus blazei
Phase I
Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer
Patients in Remission
"This
trial supports previous evidence that the ABM product is generally safe,
excluding possible allergic reaction......In Japan, researchers have
demonstrated antioxidant, antimutagenic,
antitumor,
cancer inhibitory, cancer preventive and immunoenhancing effects of Agaricus
blazei Murill experimentally"
Quality of Life in cancer Patients + Viscum
album
Review
Article: Influence of Viscum album L (European Mistletoe) Extracts on Quality
of Life in Cancer Patients: A Systematic Review of Controlled Clinical Studies
"Improvements
were mainly in regard to coping, fatigue, sleep, exhaustion, energy, nausea,
vomiting, appetite, depression, anxiety, ability to work, and emotional and
functional well-being in general and, less consistently, in regard to pain,
diarrhea, general performance, and side effects of conventional treatments.
VAEs were well tolerated“.
Cervical cancer + Boerhaavia diffusa Linn.
(Punarnava)
Inhibition
of Human Cervical Cancer Cell Growth by Ethanolic Extract of Boerhaavia diffusa
Linn. (Punarnava) Root
"In
conclusion, B. diffusa fraction 5 (BDF 5) could inhibit the proliferation of
human cervical cancer cell line, HeLa"
Bladder cancer + Antrodia camphorata
Human
urinary bladder cancer T24 cells are susceptible to the Antrodia camphorata
extracts
"In
conclusion, ACCE is a good anti-cancer agent, being effective in inducing phase
G2M arrest, acting as an anti-proliferative, and an anti-metastatic agent
against bladder cancer cell T24 cells"
Cancer general + Taiwanofungus camphoratus
Anticancer
Effects of Taiwanofungus camphoratus Extracts, Isolated Compounds and its
Combinational use
"In
addition, various compounds have been further purified from these extracts,
such as terpenoids, maleic and succinic acids derivatives, polysaccharides, and
other compounds, and they also showed potent cytotoxicity. Besides, T.
camphoratus not only has cytotoxic effect but also produces synergistic
anticancer effect with trichostatin A, lovastatin, and taxol. It is concluded
that T. camphoratus could be considered as a potential anticancer agent to make
cancer no longer a frightening nightmare. However, clinical trials of T.
camphoratus on human subjects are absent, and the involved mechanism remains
unclear. Hence, further investigations would be required“.
Apoptotic
Cell Death and Inhibition of Wnt/β-Catenin Signaling Pathway in Human Colon
Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus
"These
results indicate that Taiwanofungus camphoratus may provide a benefit as
integrative medicine for the treatment of colon cancer“.
Prostate cancer + Curcumin
Curcumin sensitizes
TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and
angiogenesis
Curcumin is
the principal curcuminoid of the popular Indian spice turmeric, which is a
member of the ginger family (Zingiberaceae)
"The
ability of curcumin to inhibit tumor growth, metastasis and angiogenesis, and
enhance the therapeutic potential of TRAIL suggests that curcumin alone or in
combination with TRAIL can be used for prostate cancer prevention and/or
therapy“.
Ovarian cancer + Calomeria amaranthoides
Potent
cytotoxic effects of Calomeria amaranthoides on ovarian cancers
Calomeria
amaranthoides is a common Australian plant
"For
the first time both crude plant extract from Calomeria amaranthoides and EPD
have been shown to have potent anti-cancer effects against ovarian cancer“.
Lung cancer + Polygala senega
Anticancer
potentials of root extract of Polygala senega against benzo[a]pyrene-induced
lung cancer in mice
"Chemopreventive
potentials of Polygala senega against chemically induced lung cancer in mice
are confirmed“.
Breast cancer + Homeopathy
Cytotoxic
effects of ultra-diluted remedies on breast cancer cells
"Study
demonstrates that the ultra-diluted natural product remedies prescribed in the
‘Banerji Protocol’ induce cell cycle delay/arrest with subsequent apoptosis in
breast adenocarcinoma cells. Though the degree of the antisurvival effect
appeared to correlate with the presence of the wild-type p53 gene, overall
susceptibility to the inhibitory effects of the remedies appeared independent of
the functional p53 and estrogen-receptor status of the breast carcinoma cells.
Finally, the preferentially elevated cytotoxic effects on breast adenocarcinoma
cells compared with cells derived from normal mammary epithelium raises the
exciting possibility of a window of therapeutic opportunity for preferentially
eliminating breast cancer cells with minimal damage to the surrounding normal
mammary tissue by using the ultra-diluted remedies investigated in this report.
The findings of this study should encourage further preclinical and animal
investigation of these remedies as preventive and/or therapeutic treatments for
breast cancer"
Adverse Effects of cancer treatments +
Homeopathy
Homeopathic
medicines for adverse effects of cancer treatments
"254
participants demonstrated benefits from calendula ointment in the prevention of
radiotherapy-induced dermatitis, and another with 32 participants demonstrated
benefits from Traumeel S
(a complex
homeopathic medicine) over placebo as a mouthwash for chemotherapy-induced
stomatitis.
The
homeopathic medicines used in all eight studies did not seem to cause any
serious adverse effects or interact with conventional treatment"
Brain Tumour + Homeopathy
Ruta 6
selectively induces cell death in brain cancer cells but proliferation in
normal peripheral blood lymphocytes: A novel treatment for human brain cancer
Both in
vivo and in vitro results showed induction of survival-signaling pathways in
normal lymphocytes and induction of death-signaling pathways in brain cancer cells.
Cancer cell death was initiated by telomere erosion and completed through
mitotic catastrophe events. We propose that Ruta in combination with Ca3(PO4)2
could be used for effective treatment of brain cancers, particularly glioma.
Melanoma + Homeopathy
Stimulation
of lymphocyte anti-melanoma activity by co-cultured macrophages activated by
complex homeopathic medication (CHM)
"Co-culture
of macrophages with lymphocytes in the presence of the CHM enhanced the
anti-cancer performance of lymphocytes against a very aggressive lineage of
melanoma cells. These results suggest that non-toxic therapies using CHMs are a
promising alternative approach to the treatment of melanomas. In addition, they
are attractive combination-therapy candidates, which may enhance the efficacy
of conventional medicines by improving the immune response against tumor cells
Melanoma + Homeopathy
In vitro
and in vivo anticancer properties of a Calcarea carbonica derivative complex
(M8) treatment in a murine melanoma model
"We
found that M8 has at least two functions, acting as both an inhibitor of cancer
cell adhesion and invasion and as a perlecan expression antagonist, which are
strongly correlated with several metastatic, angiogenic and invasive factors in
melanoma tumors....The findings suggest that this medication is a promising
non-toxic therapy candidate by improving the immune response against tumor
cells or even induce direct dormancy in malignancies".
Liver Cancer + Hepatitis + Coffee + Green Tea
Effect of Coffee
and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by
Hepatitis Virus Infection Status
Compared
with almost never drinkers, increased coffee consumption was associated with a
reduced risk of liver cancer in all subjects
A similar risk tendency was observed in those with either or both HCV
and HBV infection. In contrast, no association was observed between green tea
consumption and the risk of liver cancer in all subjects. Our results suggest
that coffee consumption may reduce the risk of liver cancer regardless of HCV
and HBV infection status, whereas green tea may not reduce this risk
Skin Cancer + Black Tea
Tea Intake
and Squamous Cell Carcinoma of the Skin: Influence of Type of Tea Beverages
"Adjusting
for brewing time, the association between skin SCC and hot black tea
consumption suggests a significantly lower risk in consumers of hot tea
compared to nonconsumers. Our results show that tea concentration (strength),
brewing time, and beverage temperature have major influences on the potential
protective effects of hot black tea in relation to skin SCC"
Breast cancer + Malaysian tropical ginger =
Alpinia conchigera/= 'lengkuas ranting'/= 'lengkuas kecil'/= 'lengkuas
1'S-1'-Acetoxyeugenol
acetate: a new chemotherapeutic natural compound against MCF-7 human breast
cancer cells.
"It
was concluded that AEA isolated from the Malaysian tropical ginger represents a
potential chemotherapeutic agent against human breast cancer cells with higher
cytotoxicity potency than its analogue, ACA“.
It is used
as a condiment in the northern states of Peninsular Malaysia and occasionally in
traditional medicine in the east coast to treat fungal infections. In
Liver, Breast, Lung cancer + Macrothelypteris
torresiana = fern
In vitro
and in vivo antitumor activity of Macrothelypteris torresiana and its
acute/subacute oral toxicity
"Macrothelypteris
torresiana (Gaud.) Ching (Thelypteridaceae) is widely distributed in the south of
Colorectal cancer + Curcumin + radiation
therapy
Curcumin
Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to γ-Radiation by Targeting Nuclear Factor-κB–Regulated Gene Products
Curcumin is
the principal curcuminoid of the popular Indian spice turmeric, which is a
member of the ginger family (Zingiberaceae)
"Collectively,
our results suggest that curcumin potentiates the antitumor effects of radiation
therapy in colorectal cancer by suppressing NF-κB and NF-κB–regulated gene products, leading to
inhibition of proliferation and angiogenesis"
Cancer general + Russula lepida o.
rosea mushroom = Harte Zinnober-Täubling
First
isolation and characterization of a novel lectin with potent antitumor activity
from a Russula mushroom.
"In
summary, a lectin with a distinctive N-terminal sequence, sugar specificity,
hemagglutinating activity with relatively high thermostability and [Cu.sup.2+]
-induced enhancement, and potent antiproliferative and antitumor activities was
isolated from R. lepida fruiting bodies. The potent antitumor activity of RLL
is remarkable and hopefully it can be developed into an agent for cancer
therapy. This report represents an addition to the existing list of mushroom
lectins".
Cervical cancer + Angelica sinensis (Oliv)
A novel
polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the
apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway.
"Our
findings provide a novel understanding of the antitumor mechanism of this
polysaccharide from Angelica sinensis and might be helpful in developing a new
antitumor agent"
Metastatic breast cancer + Carvacrol
Anti-proliferative
effects of carvacrol on a human metastatic breast cancer cell line, MDA-MB 231
Carvacrol,
(2-methyl-5-(l-methylethyl)-phenol), is a major component of the essential oils
of oregano and thyme
"The
data in the present study clearly demonstrated anti-tumor effects of carvacrol
on human metastatic breast cancer cells, MDA-MB 231, and that the compound
could have a potential therapeutic significance in treating cancer“.
Taste and Smell alterations +
Delta-9-tetrahydrocannabinol (THC)
Delta-9-tetrahydrocannabinol
may palliate altered chemosensory perception in cancer patients: results of a
randomized, double-blind, placebo-controlled pilot trial
Taste and
smell (chemosensory) alterations are common and distressing among advanced
cancer patients
Delta-9-tetrahydrocannabinol
(THC) is the main psychoactive substance found in plants of the species
Cannabis sativa
"THC
may be useful in the palliation of chemosensory alterations and to improve food
enjoyment for cancer patients".
Lung cancer + Ocimum gratissimum
Ocimum
gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma
Cell A549
"In
conclusion, the present study provides evidences that OGE treatments
significantly alter viability of lung adenocarcinoma A549 cells through a
synergy of induction of apoptotic signaling and suppression of antiapoptotic
signaling, as shown in Figure 7. Moreover, OGE treatment simultaneously
inhibits the activation of ERK and enhances the activation of JNK and p38,
which is consistent with the enhanced apoptotic signaling and reduced
antiapoptotic signaling based on their well-known effects on these signal
cascades (Figure 7). By manipulating both arms of apoptotic and antiapoptotic
pathway, OGE represents a promisingly effective chemopreventive agent against
lung adenocarcinoma“.
Advanced/Recurrent Colorectal Cancer
+ Peripheral Neurotoxicity Side Effects of Oxaliplatin + Goshajinkigan
Efficacy of
Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with
Advanced or Recurrent Colorectal Cancer
Kampō
(or Kanpō) medicine is the Japanese study and adaptation of Traditional
Chinese medicine.
"Peripheral
neurotoxicity is the major limiting factor for oxaliplatin therapy....
Concomitant
administration of GJG reduced the neurotoxicity of oxaliplatin in patients that
received chemotherapy for colorectal cancer".
Various Cancers + Ayurveda
Traditional
medicinal plants as anticancer agents from
"Recently,
a greater emphasis has been given towards the researches on complementary and
alternative medicine that deals with cancer management. Plants have long
history of use in the
treatment
of cancer. Medicinal plants maintain the health and vitality of individuals,
and also cure various diseases, including cancer without causing toxicity. Plants
derived components have played an important role in the development of several
clinically useful anticancer agents. In different region of Chhattisgarh many
traditional healers use various medicinal plants for treating of various
cancer. This review revealed that many of medicinal plants used by traditional
healer are reported to have scientific evidence. There is a need to explore the
plants which are not reported scientifically by in-vitro or in-vivo screening
methods. These plants can provide potential bioactive compounds for the
development of new ‘leads’ to combat cancer diseases"
Breast Cancer + Exercise
Effects of
exercise on breast cancer patients and survivors: a systematic review and
meta-analysis
"Exercise
is an effective intervention to improve quality of life, cardiorespiratory
fitness, physical functioning and fatigue in breast cancer patients and
survivors...Exercise also led to significant improvements in physical
functioning and peak oxygen consumption and in reducing symptoms of fatigue...
Larger trials that have a greater focus on study quality and adverse effects
and that examine the long-term benefits of exercise are needed for this patient
group“.
Breast Cancer Recurrence + Soy Isoflavones
Effect of
soy isoflavones on breast cancer recurrence and death for patients receiving
adjuvant endocrine therapy
"High
dietary intake of soy isoflavones was associated with lower risk of recurrence
among post-menopausal patients with breast cancer positive for estrogen and
progesterone receptor and those who were receiving anastrozole as endocrine
therapy“.
Cancer General, Metastasis, Ovarian Cancer, Melanoma + Ginseng
Chemistry
and Cancer Preventing Activities of Ginseng Saponins and Some Related
Triterpenoid Compounds
"Anti-tumor
activities are the properties characteristic not only to Ginseng saponins but
also to other pentacyclic triterpenes.It is noteworthy, however, that
ginsenosides, tetracyclic
dammarane-type
triterpenoid saponins, could be applied safely due to their mostly non-toxic
and non-hemolytic characteristics. Ginseng has been employed in Chinese
medicine and folklore medicine in the
Liver Cancer + Panax notoginseng
Anti-proliferative
effects of raw and steamed extracts of Panax notoginseng and its ginsenoside
constituents on human liver cancer cells
"Steaming
increased the concentrations of ginsenoside Rh2, Rk1, Rk3 and 20S-Rg3 and
enhanced growth inhibition of liver cancer cells. Conclusion Steaming changes
the chemical profile as well as anti-cancer biological activities of P.
notoginseng. Steamed P. notoginseng contains potential compounds for the
treatment of liver cancer"
Yoga + Breast Cancer + Fatigue
Yoga for
Persistent Fatigue in Breast Cancer Survivors: Results of a Pilot Study
There was a
significant improvement in fatigue scores from pre- to post-intervention that
was maintained at the 3-month post-intervention followup. Significant improvements were also observed
in measures of physical function, depressed mood, and quality of life. These results support the acceptability of
this intervention and suggest that it may have beneficial effects on persistent
post-treatment fatigue. However, results
require replication in a larger randomized controlled trial.
Homeopathy + Psorinum + Stomach, Gall Bladder,
Pancreatic + Liver Cancers
Psorinum
Therapy in Treating Stomach, Gall Bladder, Pancreatic, and Liver Cancers: A
Prospective Clinical Study
The
limitation of this study is that it did not have any placebo or treatment
control arm; therefore, it cannot be concluded that Psorinum Therapy is
effective in improving the survival and the quality of life of the participants
due to the academic rigours of the scientific clinical trials. This study also
cannot rule out the effects of the implemented allopathic and homeopathic
supportive measures
in the
observed results. However, the results of the study showed a fair number of
complete and partial tumor responses along with impressive survival outcomes in
difficult to treat cancer types. Therefore, randomized double-blind clinical
trial, detailed molecular, pharmacokinetics, and pharmacodynamics studies
should be conducted for further scientific exploration of this alternative
cancer treatment to determine if it can be integrated into the mainstream oncology.
Protein, Dairy Foods and Cancer
Breast Cancer + metastasis + Coenzyme Q10
Exogenous
coenzyme Q10 modulates MMP-2 activity in MCF-7 cell ine as a breast cancer
cellular model
CoQ10 is a natural lipid-soluble antioxidant.
"The
present study highlights the significance of Coenzyme Q10 effect on the cell
invasion/metastasis effecter molecules"
Breast + Prostate Cancer + Strobilanthes
crispus
Anticancer
activity of a sub-fraction of dichloromethane extract of Strobilanthes crispus
on human breast and prostate cancer cells in vitro
"Leaves
are used in folk medicine for their antidiabetic, diuretic, anticancer and
blood pressure lowering properties. Crude extracts of this plant have been
found to be cytotoxic to human cancer cell lines and protective against
chemically-induced hepatocarcinogenesis in rats.....A dichloromethane sub-fraction
of S. crispus displayed potent anticancer activities in vitro that can be
further exploited for the development of a potential therapeutic anticancer
agent“.
Chemopreventive, Cancer general + DNA damage + Moringa oleifera Lam
Moringa
oleifera Lam. leaves prevent Cyclophosphamide-induced micronucleus and DNA
damage in mice
"Moringa
species have long been recognized by folk medicine practitioners as having
value in tumor therapy"
"The
results show that the extract has anti-genotoxic effects on CP-induced lesions
in mice. The present results eventually lead us to conclude that ethanolic
extract of M.oleifera leaves possess anti-genotoxic phytoconstituents".
Lymphoma + Cacao (Theobroma cacao L.)
Antitumor
activity against murine lymphoma L5178Y model of proteins from cacao (Theobroma
cacao L.) seeds in relation with in vitro antioxidant activity
"This
study is the first report on the biological activity of semifermented-dry cacao
protein fractions with their identification, supporting the traditional use of
the plant. The albumin fraction showed antitumor and free radical scavenging
capacity, however both activities were not correlated. The protein fractions
could be considered as source of potential antitumor peptides".
Cervical cancer + Corydalis cava
Cytotoxic
activity of proteins isolated from extracts of Corydalis cava tubers in human
cervical carcinoma HeLa cells
"The
Corydalis sp. tubers are a rich source of many biologically active substances,
with the extensive use in European and Asian folk medicine. They have
analgetic, sedating, narcotic, anti-inflammatory, anti-allergic and anti-tumour
activities"
The
cytotoxic effect of studied proteins toward HeLa cell line cells has been
evident and dependent on increasing dose of the protein
Anticachexia (weight loss, anorexia and
weakness) +
Anticachectic
effects of the natural herb Coptidis rhizoma and berberine on mice bearing
colon 26/clone 20 adenocarcinoma
".In conclusion,
our study showed that C. rhizoma exerts an anticachectic effect on colon
26/clone 20–transplanted mice and that the effect is associated with tumor IL-6
production. We also suggest that berberine, its major component, might play a
role in the prevention of cachexia"
Non melanoma skin cancer, oesphageal + colon
cancer + Berberine (isoquinoline alkaloid present in roots, rhizome + stem bark
of a number of important medicinal plant species
Berberine
inhibits growth, induces G1 arrest and apoptosis in human epidermoid carcinoma
A431 cells by regulating Cdki–Cdk-cyclin cascade, disruption of mitochondrial
membrane potential and cleavage of caspase 3 and PAR
"Berberine
possesses a wide range of biochemical and pharmacological activities, viz.
antidiarrheal, antiarrhythmic and antitumor activities. Coptidis rhizoma,
containing abundant berberine, is shown to inhibit the proliferation of
esophageal cancer cells Berberine
inhibits cyclooxygenase-2 transcriptional activity in human colon cancer
cells and preliminary studies have shown
that berberine sulfate inhibits tumor promoting activity of teleocidin in
two-stage chemical carcinogenesis on mouse skin"
Breast cancer + Huanglian (Coptidis rhizoma), a
widely used herb in traditional Chinese medicine,
The extract
of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by
upregulation of interferon-β and TNF--α
in human breast cancer cells
"The
data presented here demonstrate that huanglian extract is highly effective in
inhibiting cell proliferation and inducing apoptotic cell death in MCF-7 breast
cancer cells“.
Cancer General, Liver toxicity + Berberine
(isoquinoline alkaloid present in roots, rhizome and stem bark of a number of
important medicinal plants)
Hepatoprotective
effects of berberine on carbob tetrachloride-induced acute hepatotoxicity in
rats
"Berberine
is an active compound in Coptidis Rhizoma (Huanglian) with multiple
pharmacological activities including antimicrobial, antiviral,
anti-inflammatory, cholesterol-lowering and anticancer effects. The present
study demonstrates that berberine possesses hepatoprotective effects against
CCl4-induced hepatotoxicity and that the effects are both preventive and
curative"
Cancer general + Berries - Berries contain many
known chemopreventive agents such as anthocyanins and ellagitannins that can be
greatly concentrated in freeze-dried berry powders.
Foodstuffs
for Preventing Cancer: The Preclinical and Clinical Development of Berries
"The
objective of this approach is to selectively kill specific types of cancer
cells with minimal effects on their normal counterparts. In contrast, berry
powders contain a mixture of compounds
that seem
to affect the expression levels of a wide range of cancer-related genes (to
lesser extents than therapeutic agents;), thus preventing the conversion of
premalignant cells to malignancy at doses that cause minimal or no
cytotoxicity. In this regard, berries seem to fulfill the requirement of an
“ideal” chemopreventive agent . The same is undoubtedly true of many other
foodstuffs; for example, a freeze-dried aqueous extract of broccoli sprouts was
effective at dietary levels in inhibiting chemically induced bladder cancer
with no observable toxicity in rats"
Chemopreventative, Cancer general +
Resveratrol (a dietary polyphenol derived from grapes, berries, peanuts, and
other plant sources)
Cancer
Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical
Trials
"The
anticancer property of resveratrol has been supported by its ability to inhibit
proliferation of a wide variety of human tumor cells in vitro. These in vitro
data have led to numerous preclinical animal studies to evaluate the potential
of this drug for cancer chemoprevention and chemotherapy. This review provides
concise, comprehensive data from preclinical in vivo studies in various rodent
models of human cancers, highlighting the related mechanisms of action.
Bioavailability, pharmacokinetic, and potential toxicity studies of resveratrol
in humans and ongoing interventional clinical trials are also presented. The
conclusion describes directions for future resveratrol research to establish
its activity and utility as a human cancer preventive and therapeutic
drug".
Head + Neck cancers + malodorous necrotic
ulcers (in cancer patients are of major concern as it leads to social isolation
and poor quality of life) + Eucalyptus Essential Oil
Antibacterial
essential oils in malodorous cancer patients: Clinical observations in 30
patients
"All
patients experienced complete resolution of the foul smell by only the 3rd or
4th day of therapy. As a secondary effect we saw that besides smell reduction
the oils had anti-inflammatory
effects on
neoplastic ulcers. In some patients ulcers started to heal and achieved
complete re-epithiliazation. The patients experienced great personal relief
upon resolution of their malodorous conditions. Quality of life improved
significantly with the resulting reintroduction of social contact with friends
and relatives“.
Chemoprevention + Cancer general + tea +
curcumin + Resveratrol + Pomegranate,
Lycopene + Luteolin + Genisten and other promising natural agents.
Perspectives
for Cancer Prevention with Natural Compounds
"Various
epidemiological and preclinical findings and the results of several early
clinical studies convincingly argue for a definitive role of selected dietary
products in the prevention and treatment of cancers. Many of these agents
target multiple signal transduction pathways, which vary widely depending on
cancer origin.....Since drug-associated toxicity remains a significant barrier
for currently available chemotherapeutic and chemopreventive drugs, using
natural compounds (which have better safety profiles) as adjuvant therapy with
current chemotherapeutic agents may help to mitigate drug-associated
toxicities. For example, genistein was found to sensitize prostate cancer to
radiation in animal studiesand a recent clinical trial suggested that soy
isoflavones could prevent radiation-induced bladder and bowel adverse effects
and erectile dysfunction"
Prostate cancer + curcumin. Curcumin is the
principal curcuminoid of the popular Indian spice turmeric, which is a member
of the ginger family (Zingiberaceae)
Chemopreventive
potential of curcumin in prostate cancer
"These
results are consistent with this compound’s ability to up-induce pro-apoptotic
proteins and to down-regulate the anti-apoptotic counterparts. Alone or in
combination with TRAIL-mediated immunotherapy or radiotherapy, curcumin is also
reported to be a good inducer of prostate cancer cell death by apoptosis.
Curcumin appears thus as a non-toxic alternative for prostate cancer
prevention, treatment or co-treatment“.
Melanoma + capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is
one of the major ingredients in red pepper among the most commonly and
frequently used spices in the world
Inhibitory
effect of capsaicin on B16-F10 melanoma cell migration via the
phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway
"The
present study provides novel insights into the molecular mechanisms of
capsaicin. Furthermore, anti-migration of highly metastatic B16-F10 melanoma
cells by capsaicin can be considered an effective approach for the suppression
of cancer invasion and metastasis"
Cancer General + Moringa oleifera Lam
Moringa
oleifera Lam. leaves prevent Cyclophosphamide-induced micronucleus and DNA
damage in mice
"Leaves
of M. oleifera contain rich amount of antioxidants. It is reported that
M.oleifera has 46 antioxidants and 36 anti-inflammatory compounds naturally
occurring in it. A possible explanation for the protective effect recorded in
the present investigation could be the involvement of its antioxidant and
scavenging properties. Antioxidants provide protection by scavenging reactive
oxidative species (ROS) that damage DNA and initiate diseases such as cancer.
Ethanolic extract of M.olerifera leaves have been reported to contain tannins,
saponins, flavonoids, glycosides and terpenoids. Antioxidant vitamins,
flavonoids, glucosinolates and organo-sulfur compounds have been proven to have
antimutagenic or anticarcinogenic potential“.
Vorwort/Suchen Zeichen/Abkürzungen Impressum