Melan produziert in Pineal./= altes Hormon/bestimmt Grundrhythmus und Kommunikation zwischen alle Organe/
In folgende Stufenordnung wird Melan hergestellt: 1. Ins. 2. Trypt. 3. Serot. 4. Melan.
Blutzuckerspiegel reguliert Trypt. Trypt. wird nachts umgewandelt in Melan/tagsüber in Serot. Bei Niacinmangel wird Trypt. umgewandelt in Niacin. wird aus Trypt in Pineal (und Retina/
Vergleich: Enthalten in: Sep.: Schwarze Panther [= gewöhnlicher Leopard mit einer ungewöhnlich starken Pigmentbildung (Melanismus: großen Höhenlagen und im Regenwald)].
A pigmented cell located between or beneath cells of the deepest layer of the epidermis synthesing melanin (Tortora and Grabowski, 1996:G35
Melanins are pigments appearing in the skin, hair, and the retina of the eye. Melanin is also found in non-visible anatomic parts such as the substantia nigra of the brain, the liver, and the adrenal glands.
It accumulates in pathological form in melanoma. Hyperpigmentation, an excess of eumelanin, may occur in pregnancy and from the use of contraceptive pills in the form of blotchy, brown pigmentation [chloasma]. "Melanic pigmentation is advantageous in many ways: It is a barrier against the effects of the ultraviolet rays of sunlight. On exposure to sunlight, for example, the human epidermis undergoes gradual tanning as a result of an increase in melanin pigment. It is a mechanism for the absorption of heat from sunlight, a function that is esp. important for cold-blooded animals. It affords concealment
to certain animals that become active in twilight. It limits the incidence of beams of light entering the eye and absorbs scattered light within the eyeball, allowing greater visual acuity. It provides resistance to abrasion because of the molecular structure of the pigment. Many desert-dwelling birds, for example, have black plumage as an adaptation to their abrasive habitat."
In humans [and animals], melanin exists in two basic varieties: the black or brown eumelanin and the yellow to reddish-brown, sulphur-containing phaeomelanin. Phaeomelanin produces 'red' hair. Individuals having a predominance of phaeomelanin in their hair and skin also have an impaired ability to tan, that is to produce more eumelanin in response to sunlight. Cuttlefish ink, known as sepiomelanin, is an eumelanin. [Eu]melanin binds many organic and inorganic products, gases and ions, recalling the behaviour of charcoal. This suggests a similarity between Sepia and carbons such as Carb-v., Carb-a. and Graph. Salts [sulphates] of sodium, magnesium, potassium and calcium also occur in the ink sack of Sepia officinalis. "We have good reasons to assume that the melanin of Sepia can interfere in those processes which involve alterations and anomalies in the pigmentation of the human skin. In Hahnemann's proving we find: 'Yellow spots in the face and a yellow saddle across the upper part of the cheeks and the nose.' This observation, among so great a number of others in the proving, might be overlooked, were it not for the corroboration by experience over some 130 years; the yellow-brown pigmentation in spots and patches, particularly of the face, has again and again proved to be a valuable indication for the use of Sepia. Strange as it may appear on first sight to approach an understanding of the actions of Sepia-melanin from the peculiar phenomenon of pigmentation, it leads to conceptions remarkably suited to obtain a coherent picture from the mass of seemingly disconnected symptoms. The said changes of pigmentation are subject to neuro-hormonal control, and particularly to that functional cycle in which the steroids of the adrenal and sex glands, in their reciprocal relationship to proteohormones of the pituitary, have a prominent role. During and esp. at the end of pregnancy fluctuations in the degree of skin pigmentation are conspicuous, the localized excesses usually receding after parturition. At the climacteric phase, when the oestrogen production subsides and the gonadotropic hormones of the pituitary are no longer inhibited, the yellow-brown spots and patches are often seen in a certain type of women, but anomalies of pigmentation may occur as signs of hormonal imbalance at any other phase. Although all these instances are on the border-line of normal and abnormal occurrences, they are apt to throw some light on the constitutional background of the actions of Sepia, The generalized bronze-brown pigmentation due to insufficiency of the adrenal glands is of far more pathological consequence, though there, too, we have degrees, from mid forms of so-called Addisonism to outright Addison's disease. One will not parallel the extreme insufficiency of the adrenals with the symptomatology of Sepia, but a comparison of the latter with the relative insufficiency in Addisonism is very revealing. All the characteristics of that syndrome, hyperpigmentation, hypotonus, and adynamy, reduced blood circulation and tendency to lowered body temperature, mental depression impairing concentration and pursuit of ordinary occupation, - all, though in a minor key, are well represented in the drug picture of Sepia. This must not be understood so as to justify a statement that Sepia acts on the adrenal glands, or on the pituitary for that matter, but rather via this hormonal part-system."
Feverfew (Tanacetum parthenium), St John's wort (Hypericum perforatum), rice, corn, tomato and other edible fruits. The physiological roles of melatonin in plants involve regulation of their response to photoperiod, defense against harsh environments, and the function of an antioxidant. The latter may be the original function of melatonin in organisms with the others being added during evolution. Melatonin also regulates plant growth by its ability to slow root formation, while promoting above ground growth.