Nosoden Anhang 4
[Sylvain Cazalet/H.C. Allen]
Bacillary
emulsion * Bacillinum Burnett * Bacillinum testium * Carcinosinum *
Coqueluchinum * Ergotinum * Hipozæninum * Influenzinum * Melitagrinum *
Morbillinum * Nectrianinum * Parotidinum * Pestinum * Scarlatininum *
Scirrhinum * Serum Marmorek * Tuberculin (birds) * Tuberculin (Bovine) *
Tuberculin Koch (old) * Tuberculin Koch (new - T. R.) * Tuberculous
Bouillon
Bacillinum [Burnett]
Dr James
Comptom Burnett
(1840-1901)
The idea of prescribing for phthisical
patients the sputum of anyone suffering from the same disease is old.
In 1638,
Robert Fludd, a professor of anatomy, advised, in a treatise, the following:
Sputum rejectum a pulmonico post debitam præparationem curat phthisin (Sputum
rejected from the lungs, after its
proper
preparation, cures phthisis).
Martino,
a Portuguese homœopathic physician, who resided in Rio, and died in 1854,
favored tubercina before Compton Burnett.
In 1874,
Swan, a New York homœopath, triturated, with sugar of milk, the sputum of a
tuberculous patient, and called this substance Tuberculinum.
Some
years later Burnett (a homœopathic physician of London) prepared his
Bacillinum, by triturating in alcohol a portion of lung taken from a typical
tuberculous patient in a manner so as to include
the walls
of a tuberculous cavity with their adjacent tissues, in a word, the bacilli,
debris, ptomaines and tubercles of all kinds.
In his
book, "The new cure of consumption by its own virus," 2nd edition,
1892, Burnett made the following recommendations:
1st. The virus must be administered by mouth, in what the homœopaths
call high potencies.
The lower dilutions are inadmissible.
"I have never used it below C 13 strength," says the author,
"and when I fear starting up constitutional troubles, I never go below the
100th centesimal dilution."
2nd. The doses must not be administered too frequently: one dose each
six or ten days is my rule in practice.
3rd. In a certain stage of consumption the virus no longer benefits the
case, but I have not been able to determine the exact period at which it ceases
to act curatively.
It is neither the chronicity nor the length of continuance of the
phthisis, but its degree of intensity which determines our point.
According
to Rovirata (Hom. practica of Barcelona, May, 1912) Bacillinum acts best in
acute cases: its chronic equivalent is Psorinum.
The
characteristic of Bacillinum is its rapid action.
If it
does not act at once, there is little to be expected from it.
As a
rule, it is efficacious in simple, in non-complicated and in not too advanced
cases of pulmonary phthisis.
In the
tuberculous process there are numerous complications that require special
treatment, as alcoholism, syphilis, malaria, anæmia, dyspepsia, and vaccinosis.
An
important consideration in the administration of Bacillinum is to employ it in
infrequent doses.
Mookerjee
thinks that Bacillinum has been curative in many cases of doubtful nature: that
sometimes it benefits the condition of the lungs, solely by relieving the
congestion of these organs and thus facilitating the action of other remedies.
Bacillinum
30th does not cure advanced phthisis, but one or two doses a week notably
relieve the most alarming and the most painful symptoms, as the cough, night
sweats and fever (Hom. Envoy).
Bacillinum testum
Description:
A nosode prepared from tuberculous testicle.
Clinical:
Inguinal glands, disease of.
Mesenteric glands, disease of.
Phthisis.
Testicles, tubercle of.
Characteristics:
This preparation has been used by Burnett as having a more direct
relation to the lower half of the body than the pulmonary Bacillinum.
Experience confirms the correctness of this inference: but it must not be supposed
that Bac. test. does not act in pulmonary cases, or Vice versa.
Description:
Carcinomin/nosode of Carcinoma.
Clinical:
Cancer.
Melancholia.
Worms.
Characteristics:
This is
one of the principal nosodes of cancer, and is one of Dr. Burnett's
preparations. I use it more frequently than any other as a diathesic remedy.
Burnett had a number of different cancer preparations,
and
followed his instinct largely in their use and selection. In addition to Scirrhinum,
of which I have given an account in the Dictionary, he had a preparation which
he named Durum (a Latinised form
of
Scirrhinum, as I take it). This he used in treating depraved inherited
conditions in children, such as infantile self-abuse, with good effects, which
I have confirmed. I have met with a suicidal tendency in several cancer
patients, so that the cancer nosodes may be appropriate in many mental cases,
especially where the heredity points that way.
Relations:
Compare:
Compare Scirrhinum.
Pertussinum o. Coqueluchinum:
Description:
Pertussin.
The nosode of Whooping-cough.
Clinical:
Cough, paroxysmal.
Whooping-cough.
Characteristics:
In all cases
of whooping-cough suspected or defined I give the remedy in the 30th
attenuation every four hours as a matter of routine, and as a rule it quickly
assumes control of the case and does all that is necessary. In my experience it
agrees well with all other whooping-cough remedies, and when their specific
indications appear I give them also in alternation, or else alone.
Compare:
Bell. Coc-c. Cor-r. Dros. etc.
Eyes: Coryza with hacking cough.
Face: Intense flushing with cough.
Mouth: Itching of the palate on lying
down at night.
Throat: Intense tickling in throat causing
cough.
Stomach: Vomiting or nausea at end of
cough.
Respiratory
Organs: Dyspnœa
with cough.
Sobbing
or sighing at end of cough.
Strangling
sensation with cough on waking.
Cough
provoked by intense tickling in throat - fauces or trachea.
Hacking
cough: with coryza.
Deep-sounding
croupy cough.
Spasmodic
choking cough.
Spasmodic
cough with intense flushing of face.
Cough in
frequently repeated paroxysms.
Chest: Stinging pain in or on the chest
with cough.
Description:
Ergotin. The alkaloid of Secale cornutum, Ergot of rye. Trituration.
Clinical:
Anal incontinence.
Gangrene.
Hæmorrhages.
Heart, paralysis of.
Sphincters, paralysis of.
Characteristics:
Ergotin
is best known by its physiological use as a hæmostatic in uterine and pulmonary
hæmorrhages. It acts by causing contraction of the arterioles, and its effect
is produced most promptly when it is administered by subcutaneous injection.
Its homœopathic uses are in the main identical with those of Secale, but
Ergotin will sometimes succeed when Secale fails. Secale, like Phosph. has
"wide-open anus" in its symptomatology.
Description:
Mallein, Glanderin, Farcin. The nosode of glanders of farcy.
(The disease is called "Glanders" when the catarrhal symptoms are
pronounced: "Farcy," when these are not noticeable, the skin being chiefly
affected, with deposits in the lungs. Homœopathic preparations of both have
been made. Those made from Farcy are distinguished by the letter "F."
Clinical:
Abscesses.
Bed-sores.
Boils.
Bronchitis.
Cancer.
Carbuncles.
Caries.
Catarrh, chronic.
Colds chronic.
Diphtheria.
Elephantiasis.
Erysipelas.
Glanders.
Glands, inflamed.
Hip-disease.
Liver, enlarged.
Lupus excedens.
Nasal cartilages, ulceration of.
Œdema.
Ozæna.
Parotitis.
Phlegmasia alba dolens.
Phlegmon.
Plague.
Pustules.
Putrid fever.
Pyæmia.
Scrofula.
Small-pox, confluent.
Syphilis.
Tuberculosis.
Ulcers.
Whooping- cough.
Characteristics:
Mallein,
a toxin prepared from glanders, has taken an important place in veterinary
practice of the old school as a test injection for deciding whether a horse
suspected of glanders actually has the disease or not. If the horse reacts it
is concluded there is glanders. In a number of cases in which animals have
reacted to the first injections, a repetition of the "test" has
failed to elicit reaction, thus proving that Mallein is curative as well as
diagnostic (H. W. xxxv. 149). The nosode has been used by homœopaths, at the
suggestion of Garth Wilkinson, on the phenomena of the disease as guides, and
in a large number of cases involving low forms of suppuration and catarrh,
malignant ulcerations and swellings, abscesses and enlarged glands: and also in
conditions similar in kind, but less in severity. I have used it with excellent
effect in cases of inveterate nasal catarrh and of glandular enlargement. The
nasal affection may go on to Ozæna, ulceration of nasal cartilages and bones.
Glanders
in the horse affects the lungs no less than the upper respiratory tract,
causing coughs and disseminated ulcerations and deposits throughout the lungs.
It has
cured papules and ulcerations in frontal sinuses, pharynx, larynx, and trachæa:
hoarseness: old cases of bronchitis (in old persons) where suffocation from
excessive secretion seemed imminent.
Bronchial
asthma. Whooping-cough. A cough commencing at Christmas and lasting till June
has been cured by it.
Relations:
Compare:
Bac. Avi. Luet. Variol.
The
Serpent poisons, Aurum, Cadm. s. Kali b. Hepar, Psorin.
Description:
The nosode of Influenza.
Clinical:
Catarrh.
Colds.
Influenza.
Characteristics:
The
nosode of influenza has with many practitioners taken the place of Bapt. as the
routine remedy in epidemics. It may be given in the 12th or 30th potency,
either in the form of tincture, pilules, or discs. When "colds"
appear in a family let all those who are unaffected take Ars. C 3 3x daily, and
let the patients take Influ. 30 every hour or two. This generally prevents the
spread of the trouble and clears up the "colds", whether they are of
the influenza type or not. Influenza has the property of developing old
troubles, and thus it takes an infinite variety of forms in different persons,
so that Influ. need not be expected to cure all cases unaided, or indeed, to be
appropriate to every case.
Relations:
I find
Influ. compatible with Act-r. Ars. Bell. Bry. Hep. Merc. and many others.
Melitagrinum:
Dr Thomas
Skinner (1825-1906)
Description:
The nosode of Eczema capitis. Dr. Skinner's Fluxional Centesimal
attenuations.
Clinical:
Crusta lactea.
Eczema capitis.
Characteristics:
Dr.
Skinner has given a brief account of this nosode, introduced by him, in H. W.
xvii. 89. He prepared it from the lymph and blood of a case of eczema capitis.
Very
severe cases were cured with Melit. CM (F. C.) given in single doses at
considerable intervals. In one case there was an initial aggravation.
Description:
The nosode of Measles.
Clinical:
Catarrh.
Coryza.
Cough.
Ear, affection of.
Eye, affections of.
Measles.
Skin, affections of.
Characteristics:
The
well-known symptoms which characterize an attack of measles may be taken as
guides for its homœopathic use. Its chief use hitherto has been as a
prophylactic against infection, and to clear up
after-effects of an attack. As the measles
poison has a great affinity for the mucous passages, the eyes, the ears and the
respiratory mucous membranes, Morb., may be used in such cases like any other
homœopathic remedy, when the symptoms correspond.
Dose: Use
30 dilution 8 or 10 globules in 6 oz. of water a dessert-spoonful every 2
hours, as a prophylactic, a dose twice or thrice daily.
Relations:
Complementary:
Bell. Compare: Puls. Hep. Merc. Sul.
Description:
Nosode of cancer of trees (Nectria ditissima). Dilution. Trituration of
the parasite.
Clinical:
Carcinoma.
Epithelioma.
Characteristics:
Nectrianinum
is a clear liquid of a yellowish brown hue which was prepared by Bra and
Chaussé (Med. Rev. of Rev. April, 1900, quoted H. M. xxxv. 533) as follows:
Injected
into healthy animals in 5 c. c. doses several times a week no result is
observed. In cancerous men and animals, on the contrary, the injections cause a
rise of temperature in from 2 - 4 hours of 1° - 3°.
If the
dose is increased the hyperthermia is accompanied by chills, sensation of cold,
accelerated pulse, palpitation, headache, thirst. The crisis terminates after
some hours in polyuria and profound sleep.
In very
advanced cancer reaction may not occur. In a summary of the results the
observers say that Nectrianinum has caused: "Arrest or diminution of
hæmorrhages: suppression of fetid discharges: a tendency at times to
epidermisation of the neoplasm with a corresponding well-defined arrest in its
evolution." The patients were < when treatment was discontinued and
> when it was resumed. A maximum of 4 c. c. per day was never exceeded.
Relations:
Compare:
Scirrh. Epitheliomin.
Description:
The nosode of Mumps.
Clinical:
Glandular affections.
Meningitis.
Mumps.
Orchitis.
Salivation.
Characteristics:
Parotidinum
has been used as a prophylactic against infection by mumps. In this instance it
is generally given in the 6th or 30th two or three times a day to those exposed
to infection. In the disease itself
it may be
given every four hours, either by itself or alternated with other indicated
remedies. The well-known complications which sometimes occur with mumps,
cerebral inflammation and orchitis suggest
its
possible use in these conditions.
Relations:
Compare:
Merc.
Description:
Plaguinum. Nosode of Plague. Trituration of the virus.
Clinical:
Bubo.
Plague.
Typhus.
Characteristics:
The
prophylaxis and treatment of plague with injections of more or less modified
virus of plague by old school practitioners affords evidence that the nosode of
plague is available, like other nosodes, for the treatment of cases of the
disease from which it is derived.
Description:
The nosode of Scarlatina or Scarlet Fever.
Clinical:
Albuminuria.
Nephritis.
Scarlet fever.
Skin affections.
Throat sore.
Characteristics:
Scarlatinin
has been used, like other nosodes, for the prevention and for cure of the
disease from which it takes origin. But its well-known affinity for the skin,
throat and kidneys suggests its applicability for affections of those organs.
Relations:
Bell. is
the nearest analogue and should be its antidote, and the various Mercuries come
next.
Compare
also: Apis, Ars. Rhus-t. Morb. Diph.
Description:
Carcinominum. The nosode of Scirrhous Cancer. Trituration.
Clinical:
Breast, cancer of.
Cancer.
Cancerous diathesis.
Glands, enlarged.
Hæmorrhages.
Varicosis.
Worms.
Characteristics:
Burnett
is my authority for this nosode. He proved it on himself, and produced "a
tremendous sinking at the navel," which he regarded as a keynote for its
use. Scirrh, has aided the cure of many cases of breast tumour in Burnett's
hands. With it he cured a man of hard glands which appeared on the left side of
the neck after other glands had been removed by the patient's brother, a
surgeon. Hæmorrhages and varicosis of legs and feet, with purple points, have
also been cured by Burnett with Scirrh. A patient to whom Burnett had given
Scirrh. mentioned to him that it had caused the passage of an enormous number
of threadworms. On this hint Burnett gave it with great success in many cases
of this troublesome complaint: and I have verified this experience. In
inveterate cases where Cina and Teucr. have given little relief, Scirrh. has
wrought a great change for the better. < 17 – 18 h. and irregularly on
through the night.
Dr Léon Vannier (1880-1963)
We are here concerned with his
antituberculous, not with his antisteptococcic, serum. Marmorek does not
believe in a tuberculous infection: for him there is only an intoxication, and
it is only antitoxins
that he
has tried to manufacture. Without discussing here the advantages or
disadvantages of this serum in the doses advised by the author, and without
speaking of the accidents that the remedy has caused through its excessive
strength in hypodermic injection (accidents that suggest its employment per
rectum), I will begin at once with that side of the question which interests
us: the employment of the serum
in
homœopathic doses, diluted to the 6th, 10th, or 30th centesimal attenuation,
and administered by mouth. Nebel was the first to advise the serum in medium
homœopathic doses. Leon Vannier, upon the advice of Nebel, has employed this
dilute serum, and he has been able to collect 530 observations grouped by him
into two categories, the tuberculinics (those predisposed), and the
tuberculous.
He places
in connection with the group of tuberculinics certain conditions which, by a
few modern authors, would be considered prodromes of tuberculosis, a
classification which suggests the similarity between tuberculinics and the
pre-tuberculous or good subjects for tuberculosis. According to Vannier,
tuberculinics present themselves under various aspects:
1st. the febrile (febrile without apparent reason):
2nd. persons subject to colds (persons who have cold after cold, and
coryza after coryza during the winter):
3rd. dental patients (persons predisposed to tuberculous, said he, seem
to make a rendezvous of the dentist's chair):
4th. constipated persons:
5th. cardiac patients (especially functional heart disease).
All these
types of intoxicated persons are benefited by one or more doses of the diluted
serum of Marmorek (l'Homœopathie française, May, 1912). Vannier passes then to
the truly tuberculous.
The serum
of Marmorek, being essentially an antitoxic serum, suits the pulmonary
tuberculous, who, notwithstanding the gravity or extent of their lesion, have
poor resistance. Vannier has always
observed
a rapid improvement in the general condition, and a progressive increase in the
weight of those under the influence of the diluted serum: but he has remarked
that on the 1st, and especially
2nd day
following the absorption of the serum, there appeared pains in the apex of the
lungs, an obstinate cough, and a state of unaccountable fatigue. Then there is
a return to normal conditions.
This
series of transient aggravations prepares the way for a progressive
improvement. Everything continues as if there existed a truly negative period,
similar to that caused by the vaccines, this negative
period
being followed by a positive condition much more prolonged, and in the latter
the cure is completed.
Dr Antoine Nebel
(1870-1954)
This is also
the opinion of Nebel. In osseous tuberculosis the serum has always brought a
considerable improvement of the pains (clinical observations of Pott's disease
and spina ventosa), and with this improvement the rapid diminution and even the
complete disappearance of the violet discoloration so characteristic of
tuberculous fistulæ. When there is pus, the discharge for the first few days is
more abundant and then gradually diminishes. Two cases of peritoneal
tuberculosis have been successfully treated with the serum, one by Vannier, the
other by Mondain. Three cases of tuberculosis of the urinary tract were cured
with the diluted serum (l'Homœopathie française, April, 1912). Tuberculous
meningitis: one favorable case by Renaud-Badet.
Regarding
a case of peritoneal tuberculosis, Mondain says: "If the case is acute, or
the organism too much depressed, we furnish to the cells in peril the prepared
antibodies by administering a dilution of the antituberculous serum of
Marmorek: later, when the general condition has sufficiently recovered so as to
easily allow the patient to manufacture his own antibodies, we may, after
studying his constitution, his temperament, and his symptoms, make a choice of
the most suitable tuberculin, both to complete the cure and to effect
immunization. Is not this method of isopathic protection the best ? It is the
one that nature herself employs in her spontaneous cures. We, faithful servants
of nature, only imitate and assist her."
Aviare: =
tuberculin of birds
It was
tried in human tuberculosis by Pierre Jousset, nearly 20 years ago. Although
the patients requested the remedy, Jousset, Sr. has never confirmed any effects
in human tuberculosis. I have,
in
speaking on page 161 of the homœotherapy of the tuberculins, insisted
especially upon the value of Aviare in the non-tuberculous diseases of the
respiratory organs. According to José Galard,
Aviare,
in tuberculosis, is especially indicated when the symptoms are acute and of
such a nature that they may develop into broncho-pneumonia, Wheeler, also,
prefers Aviare in acute cases, especially
in the
exacerbations of chronic pulmonary affections with profuse expectoration. His
favorite dilution is the 100th, repeated every twenty-four or forty-eight
hours, until improvement appears.
An
enthusiastic student in Allentown, a Mr. Schmid, made a very good proving: and
one of our nearest friends (an experienced prover, a former engraver, Bechlert,
by name, at that time a paralyzed man) persuaded all his acquaintances, a dozen
of women and girls, and some boys, to prove the higher preparations. None of
his provers knew anything of the origin of the drug, and they were examined
every day with great care, according to the advice of Hahnemann.
Tuberculinum
bovinum: (cattle).
It's prepared in homœopathic
attenuations, in London, by Epps and Nelson. Moir and Hay think that, in
accordance with what they have seen of its use, the bovine tuberculin gives
better results than
does the
ordinary human tuberculin. According to Ord, an occasional dose of bovine
tuberculin in the 30th is undoubtedly useful to those who have been treated by
the old method of frequent doses of ordinary tuberculin, but Ord has never been
successful in completely curing a case by bovine tuberculin only. Bishop has
mentioned the necessity, when the condition remains stationary, of changing the
human tuberculin for the bovine.
Tuberculinum
Koch:
A splendid article of Harlan Wells',
entitled "A practical and favorable method of treating pulmonary
tuberculosis with tuberculin," has appeared in the Journal of the American
Institute of Homœopathy, February, 1912. Wells employed the old tuberculin of
Koch in hypodermic injection. Wells always commenced the treatment with the 6th
decimal dilution. If the patient was an adult, and if no reaction followed the
first dose, he gave one-tenth of a cubic centimeter of the 5th decimal. He then
increased the dose one-tenth cubic centimeter at each injection, until it
reached the 3x dilution. If a reaction followed, Wells waited that everything
might be calm, and then resumed the dilution above the one that caused the
reaction. Concerning the intervals between the injections, he generally gave
two injections a week till the third week. It will take at least two or three
moths to judge if the treatment has proved of any permanent benefit.
Wells
cites many cases where the bacilli disappeared from the sputum. He explains the
favorable action of the tuberculin in about the usual manner, namely, that it
stimulates the cells of the body, enabling them to form agglutinins, opsonins,
and other substances related to the immunizing process. In a patient whose
nutrition is poor, and who is functionally disordered, the organism is not in
condition to respond to the stimulative action of tuberculin, consequently the
tissue cells cannot form immunizing substances.
In the
opinion of Moll, of Brixen, tuberculin is not only a specific for pulmonary
tuberculosis but it is also a good remedy for bony suppurations, especially in
cases that have been rebellious to other remedies. In these conditions we must
employ only the high dilutions.
The 60th
decimal gives prompt reactions. Moll cites many favorable cases in which he
used the 250th decimal dilution.
Lambert
makes frequent use of Tuberculinum 200th, one dose every week: the 30th
generally producing aggravations (British Hom. Society). It has been remarked
that homœopaths speak as often of aggravations with the high dilutions as with
the low. Do not the phenomena of anaphylaxis occur more commonly as a result of
small quantities ? Yet medicinal aggravations are less pronounced in
homœopathic than in physiological doses, weak as the latter may be.
In a
brochure entitled The Modern Treatment of Tuberculosis Barcelona, 1907, Olive y
Gros states that he employs the tuberculin of Koch generally in the 200th,
residual tuberculin in the 200th, dialyzed tuberculin in the 100th, the
filtered bouillon of Denys in the 200th, chloroformed tuberculin in the 100th,
the serum of Marmorek in the 30th, the serum of Ferran in the 12th, and Aviaire
in the 100th.
Tuberculinum
residuum: Koch Nos. (Tuberculin T. R.)
The new tuberculin of Koch, as well as
the emulsions and filtrations, must according to Trudeau, be preferred, because
with it the tendency to febrile reaction is less than is the case with the old
tuberculin. Jager, of Hildesheim, employs the new tuberculin in the 6th and 7th
decimal, by mouth. Scheidegger, of Aarau, Switzerland, has had the best success
with the T. R. (residual tuberculin) in low dilutions, administered at long
intervals, in the early stages of the disease.
Tuberculinum Denys:
Humeau and Ravet, of Havre, have
published lately the results of their practice (Art médical, January, 1912, and
Archives médico-chirurgicales de Normandie, March, 1912).
These physicians
are using the tuberculin of Denys, in true homœopathic doses, either
hypodermically or by mouth.
Humeau
and Ravet never commence lower than the ninth decimal, and often much higher.
Once the
initial dose is fixed, 9th, 12th, or sometimes the 15th decimal (20th in one
case), the treatment is continued by three injections a week, until the 3x
dilution is reached. If there is no reaction, these doses are of 1/10, 2/10,
3/10, etc. of each solution. After 9/10 of one dilution, they pass to the next lower
decimal dilution, so as to have a regular and constant progression. When a
reaction is produced, it is an invariable rule to suspend all further
injections, until the disappearance of all reactionary phenomena. The custom of
Humeau and Ravet is, even at the beginning, to avoid aggravations, they never
begin at once with tuberculin. In treating a case of pulmonary tuberculosis the
patient is first given hygienic treatment, more or less severe, sometimes rest
in bed, the individual requirements governing each case. The patient's
temperature is taken, he is given, according to the indications, an internal
remedy, and meanwhile, before the injection of tuberculin, is given close
study.
This
minute knowledge of the patient is necessary for fixing the initial dose, and
the character of the further specific treatment. The dose, that is, the
intensity of the excitation, must be such that the affection will take on a
more acute form during which, temporarily, the patient will be weakened. Its
action, to be effectual, however must not pass beyond the successful
reactionary struggle of which the organism of the patient is capable. Humeau
and Ravet have seen the great majority of their curable patients obtain from
the treatment, amelioration and even complete cure: but besides these results
they have had, also, cases where the same remedy in widely different dosage,
did not appear to act. They were unable to judge in advance the favorable or
unfavorable reaction. In another series of tuberculous cases these physicians
have adhered to one and the same dilution satisfactorily, without increasing
the dose.
Dr Pierre Jousset (1818-1910)
P.
Jousset gives the filtered tuberculous bouillon of Denys successfully in the
6th, 10th, and 12th decimal. As soon as a reaction appears, he prefers to
suspend the injections entirely rather than continue with weaker doses. In
another article, collaborated with G. Proust (Art médical, Nov. 1907),
Jousset's opinion, from an experience with more than forty phthisical patients,
was that the bouillon of Denys, with a careful technique, is entirely
inoffensive, and that its beneficial influence is shown by the constitutional
condition, the febrile movement, and even by the condition of the pulmonary
lesion. Jousset remarks that, in this treatment, the cure is assured when the
injections of pure filtered bouillon do not produce an increase in temperature.
In such
case, and then only, we must discontinue the treatment.
Tuinzing
uses the 7th and 8th decimals.
Rankin,
in a sanatorium, employed doses from 1/1000 of a milligram to 10 milligrams.
I have
personally given, by mouth, the tuberculin of Denys in the form of globules
saturated with the high dilutions, the 100th, the 200th and the 500th
centesimal. As extreme as these dilutions appear, it is yet with them that I
have in advanced cases most frequently and most easily arrested the progress of
the disease: I refer to cavities.
Again, as
extraordinary as may seem what I am about to say, these tuberculous cavities
are not protected from medicinal aggravations, not even against these
imperceptible doses that old school physicians have termed quackery. To deal
with the theory of attenuations in this cursory manner is vain, when we have
examined from every angle, and confirmed the facts. I have often arrested,
temporarily, with these high dilutions, the development of a progressive
tuberculosis characterized by a persistence of the fever (but not the fever
having great fluctuations, from streptococci or acute pneumococcal infection),
an incessant cough, abundant expectoration, pulmonary perituberculous
congestion, and anorexia. I give one single dose of ten globules of the 100th,
200th, or 500th: in the beginning I repeat the dose every three to eight days,
till an improvement takes place (requiring sometimes only two or three doses).
As long as the improvement continues we must not renew the dose. I have thus
been able to lengthen the intervals between the doses, from eight to twenty-one
days, and from fifteen days to a month. The tuberculous quiescence may last
many months. In a patient who appeared unusually improved and who had only a
slight expectoration in the morning, I had this expectoration examined: it
still contained a number of the bacilli of Koch, and some pneumococci. Here,
then, was a case of temporary cessation of perituberculous congestion all about
the tuberculous faci, without a cure of the tuberculosis. I have at present
among my patients a young girl with a cavity in which the tuberculous process
progressed rapidly, and who during her paroxysms of coughing vomited almost
incessantly. For the past year and a half this patient, taking Denys' 500th,
has kept fairly well. The cough having almost left her, the poor girl announces
to me that she is cured. No class of persons exceeds the tuberculous in
optimism ! Temporary as the ameliorations are, they constitute nevertheless, a
real progress in tuberculinotherapy, and the above method of treatment far
excels the sedative syrups, which latter have a depressing effect, excels
equally Creosote, which ruins the stomach, and superalimentation, which
occasions enteritis. There may, of course, be some advantage in employing,
during the interval of the doses, any accessory measure which may assist in
bringing about a favorable result. But the two cases that I have cited, and
also others, have been treated solely by these attenuated doses of Denys',
without the employment of any adjuvants. Many of the patients were too poor to
undergo expense. The tuberculin of Denys' in high dilution is also used by
Nebel, Vannier, Chiron, and others.
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