Krebs Anhang 2
http://www.kompetenznetz-kokon.de/
Honig
18/12/2011
Prostate cancer + Pomegranate
"In conclusion, these studies reveal novel interactions between the
IGF system and pomegranate-induced apoptosis, and suggest that pomegranate
products modulate the tumor production and responsiveness to IGFs and the
IGFBPs. As IGFBP-3 is currently being tested in humans as a treatment for
prostate cancer and pomegranate supplements are becoming popular as adjuvant
nutritional treatments for this disease, we propose that these agents may
emerge as useful in the management of prostate cancer“.
Pomegranate extract inhibits androgen-independent prostate cancer growth
through a nuclear factor-κB-dependent mechanism
"Extending the duration of the androgen-dependent state could
potentially prolong life expectancy of prostate cancer patients and delay or
prevent the need for additional hormonal therapy or chemotherapy. In this regard,
our finding that PE delayed the growth and emergence of androgen independence
in our xenograft model may be particularly germane. Of importance, our group
showed previously that dietary fat reduction delayed the emergence of androgen
independence and prolonged survival using a similar xenograft model (36).
Future research will focus on potential additive and/or synergistic effects of
combining a low-fat diet with PE. Based on our results, we propose that PJ
could have potential as a dietary agent to prevent the emergence of androgen
independence and suggest that this may be a high priority area for future
clinical investigation"
Colon cancer + Chinese Red Yeast
Rice = red fermented rice, red kojic rice, red koji rice, anka, or ang-kak, is
a bright reddish purple fermented rice, which acquires its colour from being
cultivated with the mold Monascus purpureus. "RYR, a traditional Chinese
food herb and a modern dietary supplement, has demonstrated in vitro effects
including inhibition of proliferation and stimulation of apoptosis in human
colon cancer cells by mechanisms involving MK and the red yeast pigment
fraction"
Ovarian, Cervical, Breast,
Phytochemicals, antioxidant properties and anticancer investigations of
the different parts of several gingers species (Boesenbergia rotunda,
Boesenbergia pulchella var attenuata and Boesenbergia armeniaca) "In the
cytotoxicity assay, B. rotunda showed the most prominent and promising result
as anticancer medicinal plant. It showed positive antiproliferative effect
against five cancer cell lines: ovarian (CaOV3), breast (MDA-MB-231 and MCF-7),
cervical (HeLa) and colon (HT-29) cancer cell lines with 3-(4,
5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay conducted.
In addition, the rhizome of B. pulchella var. attenuata and B. armeniaca shown
positive result in cytotoxicity assay tested against breast cancer (MCF-7).
Thus, the Boesenbergia species investigated would be a promising anticancer
remedy for breast cancer“.
Cancer Prevention + Nutrition
"Recent evidence suggests that nutrients and other bioactive food
components protect against cancer through modulation of miRNA expression.
Moreover, dietary factors have been shown to modify miRNA expression and their
mRNA targets in various cancer processes, including apoptosis, cell cycle
regulation, differentiation, inflammation, angiogenesis, and metastasis as well
as pathways in stress response. Herein, we provide a brief overview of dietary
modulation of miRNA expression and its potential role in cancer prevention.
Understanding the affect of dietary factors on miRNA expression and function
may provide insight on prevention strategies to reduce the burden of cancer“.
Cancer general + Vitamin C
Vitamin C: A Concentration-Function Approach Yields Pharmacology and
Therapeutic Discoveries
"Pharmacologic ascorbate can elicit cytotoxicity toward cancer
cells and slow the growth of tumors in experimental murine models. The effects
of pharmacologic ascorbate should be further studied in diseases, such as
cancer and infections, which may respond to generation of reactive oxygen
species via H2O2“.
Cancer general + European Mistletoe
Survival of cancer patients treated with mistletoe extract (Iscador): a
systematic literature review.
"Pooled analysis of clinical studies suggests that adjuvant
treatment of cancer patients with the mistletoe extract Iscador is associated
with a better survival. Despite obvious limitations, and strong hints for a
publication bias which limits the evidence found in this meta-analysis, one can
not ignore the fact that studies with positive effects of VA-E on survival of
cancer patients are accumulating"
Rectum,
Use of Iscador an extract of European Mistletoe (Viscum album), in Cancer Treatment:
Prospective Nonrandomized and Randomized Matched-Pair Studies Nested Within A
Cohorot Study
"Mistletoe extracts, which contain a complex of oncologically
relevant active substances andexert a variety of anticancer effects, appear to
prolong survival times in patients with various tumor types. In the studies
described here, efficacy was observed in patients with rectum carcinoma, colon
carcinoma, stomach carcinoma, breast carcinoma (with or without axillary
metastases or remote metastases), and small cell and non-small-cell
bronchogenic carcinoma. The study findings support the claim of
anthroposophical medicine that mistletoe therapy is generally effective for
treating cancer, irrespective of tumor type“.
Anticancer Drugs + DHA + Improved
Efficacy
Docosahexaenoic acid: A natural powerful adjuvant that improves efficacy
for anticancer treatment with no adverse effects.
"The data suggest that DHA is a safe, natural compound that can greatly
improve the anticancer properties of anticancer drugs. Use of DHA with
anticancer treatments provides an avenue to therapeutic improvement that
involves less risk or side effects for patients and reduced regulatory burden
for implementation“.
There are two major types of omega-3 fatty acids in our diets: One type
is alpha-linolenic acid (
and in walnuts.
Lung cancer + Silybum marianum / St.
Mary's Thistle
Silibinin modulates TNF-α and IFN-γ
mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse
lung epithelial LM2 cells
"Together, we showed that STAT3 and STAT1 could be valuable
chemopreventive and therapeutic targets within the lung tumor microenvironment
in addition to being targets within tumor itself, and that silibinin inhibits
their activation as a plausible mechanism of its efficacy against lung
cancer"
NB Silibinin (INN), also known as silybin, is the major active
constituent of silymarin, standardized extract of the milk thistle seeds
(Silybum marianum)
Melanoma + Radiotherapy + Survival +
Withania somnifera / Ashwaghanda
Enhancement of the Response of B16F1 Melanoma to Fractionated
Radiotherapy and Prolongation of Survival by Withaferin A and/or Hyperthermia
" In conclusion, WA is a better radiosensitizer than HT in
fractionated regimen and the response of radioresistant tumors like melanoma
can be significantly enhanced by combining nontoxic doses
of WA with fractionated RT, with or without HT, allowing decrease in
radiation dose“.
Spirituality + cancer
Positive Changes, Increased Spiritual Importance, and Complementary and
Alternative Medicine (
"our study offers important insights into the spiritual experience
following cancer among a large sample of survivors with different tumor types.
Positive changes are common among survivors, even among those living with
cancer...The strong relationship between
Bojungikki-Tang (= a Chinese classic
herbal formula) + Cancer-related fatigue
Bojungikki-Tang for Cancer-Related Fatigue: A Pilot Randomized Clinical
Trial
"Despite its limitations, we believe that our study reports
interesting data on the potentials of Bojungikki-tang to be used for
cancer-related fatigue and to improve quality of life in cancer patients"
Glioblastoma + Cannabidiols
Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human
Glioblastoma Cell Proliferation and Survival
"The treatment of glioblastoma cells with both compounds led to
significant modulations of the cell cycle and induction of reactive oxygen
species and apoptosis as well as specific modulations of extracellular
signal-regulated kinase and caspase activities. These specific changes were not
observed with either compound individually, indicating that the signal
transduction pathways affected by the combination treatment were unique. Our
results suggest that the addition of cannabidiol to Δ9-THC may improve the overall
effectiveness of Δ9-THC
in the treatment of glioblastoma in cancer patients“.
Cancer general + Calcitriol (active
form of Vitamin
D)
Calcitriol in cancer treatment: From the lab to the clinic
"1,25-Dihydroxyvitamin D (calcitriol), the most active metabolite of
vitamin D, has significant antineoplastic activity in preclinical models.
Several mechanisms of activity have been proposed. These include inhibition of
proliferation associated with cell cycle arrest and, in some models,
differentiation, reduction in invasiveness and angiogenesis, and induction of
apoptosis. Proposed mechanisms differ between tumor models and experimental
conditions, and no unifying hypothesis about the mechanism of antineoplastic
activity has emerged.....Further work is needed to elucidate the molecular
mechanisms of antineoplastic activity and optimal clinical applications of
calcitriol in cancer. "
NB-Calcitriol also called 1,25-dihydroxycholecalciferol or
1,25-dihydroxyvitamin D3, is the hormonally active form of vitamin D
Esophageal cancer, colorectal cancer
and hepatoma and Archidendron lucidum (Benth.)
Anti-tumor effect of Archidendron lucidum (Benth.) against esophageal
cancer, colorectal cancer and hepatoma
"Our results indicate that optimal dose of MEAL might possess the anti-tumor
effects against esophageal, hepatocellular and colorectal cancers with a
relative safety profile. Accordingly, we are purifying effective and less toxic
compounds from MEAL“.
Renal cancer + Guan-Jen-Huang (Aeginetia indica
Linn.)
Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica
Linn.), on Renal Cancer Cell Growth and Metastasis
"These results suggest that GJH extract has a synergistic effect on
apoptosis induced by chemotherapeutic agents and an inhibitory effect on cell
adhesion, migration, and invasion, providing evidence for the use of
water-based extracts of GJH as novel alternative therapeutic agents in the
treatment of human renal cancer“.
Leukemias, lymphomas, multiple
myeloma, brain cancer, melanoma and skin, lung, prostate, breast, ovarian,
liver, gastrointestinal, pancreatic and colorectal epithelial cancers +
Curcumin
Potential applications of curcumin and its novel synthetic analogs and
nanotechnology-based formulations in cancer prevention and therapy
"Curcumin has attracted great attention in the therapeutic arsenal
in clinical oncology due to its chemopreventive, antitumoral,
radiosensibilizing and chemosensibilizing activities against various types of
aggressive and recurrent cancers. These malignancies include leukemias,
lymphomas, multiple myeloma, brain cancer, melanoma and skin, lung, prostate,
breast, ovarian, liver, gastrointestinal, pancreatic and colorectal epithelial
cancers. Curcumin mediates its anti-proliferative, anti-invasive and apoptotic
effects on cancer cells, including cancer stem/progenitor cells and their
progenies, through multiple molecular mechanisms.
..Taken together, these studies carried out in the last ten years have
indicated that curcumin may act on multiple oncogenic targets frequently
deregulated in cancer cells, including cancer stem/progenitor cells with stem
cell-like properties, during the progression of most human aggressive
cancers"
Doxorubicin-induced Cardiotoxicity +
Curcuma longa
Cardioprotective effects of Curcuma longa L. extracts against
doxorubicin-induced cardiotoxicity in rats
"Oral administration of Curcuma longa ethanolic or water extract
(200 mg/kg) prior to doxorubicin produced a significant protection which was
evidenced by significant reduction in mortality, CK-MB and LDH -activities.
Moreover, they significantly increased GSH markedly, decreased cardiac calcium,
and cardiac and serum MDA. In addition, both extracts significantly reduced
serum nitric oxide, increased cardiac ascorbic acid, and ameliorated the
antioxidant enzymes activities. In conclusion, Curcuma longa extracts renders
resiliency against doxorubicin cardiotoxicity due to their contents of
polyphenolic compounds that might serve as novel adjuvant therapy with doxorubicin“.
Thoracic radiotherapy + seed
DIETARY FLAXSEED PREVENTS RADIATION-INDUCED OXIDATIVE LUNG DAMAGE,
INFLAMMATION AND FIBROSIS IN A MOUSE MODEL OF THORACIC RADIATION INJURY
"In summary, this study evaluates a non-toxic, widely available
nutritional supplement that offers long term radioprotective effects in the
setting of thoracic radiotherapy. Potential mechanisms of the effects of
prolonged FS feeding include altering immediate XRT-induced markers of lung
damage, creating a baseline radioprotective state prior to XRT, and providing
high levels of circulating antioxidants from the continued metabolism is of
bioactive lignans“.
Cancer general + Rhaphidophora
korthalsii
Immunomodulatory Effect of Rhaphidophora korthalsii on Natural Killer
Cell Cytotoxicity
"In this study, stimulation of the immune system by R. korthalsii
methanol extract had significant effects on proliferation, NK cell population,
and cytokine expression in the host, which further enhanced the cytolytic
activity of the immune cells. Up till now, 5,6-dihydroxyindole (DHI) is the
only compound successfully isolated from R. korthalsii. However, role of DHI on
the immunomodulatory effect of R. korthalsii methanol extract and the other
potential active secondary metabolites that play an important role in this
immunostimulatory effect are still unknown. Thus, future study should focus on
isolation and evaluation of active metabolites from the extract that
contributes to the immunomodulatory effect against the NK cell“.
Prostate cancer + Lycopene
Multitargeted therapy of cancer by lycopene
"These epidemiological studies are supported by numerous in vitro
assays using cell cultures that show anti-cancer activities and cancer
chemoprevention activities of lycopene in many cell lines including prostate cancer
cells. These activities include inducing apoptosis, inhibiting metastasis,
preventing oxidative stress, and up-regulating the antioxidant response element
so that cells can produce cytoprotective enzymes against prooxidants and
electrophiles. In vivo animal studies and Phase I and II clinical trials have
shown that lycopene supplements are non-toxic and that lycopene is orally
bioavailable. Furthermore, lycopene is concentrated in prostate tissue and
localized to the nucleus. In addition, some oxygenated metabolites of lycopene
have been identified, and might be active as chemoprevention agents“.
NB lycopene is responsible for the red pigmentation of ripe tomatoes and
some other edible fruits such as watermelon and papaya.
Esophageal squamous cell carcinoma,gastric
+ hepatoma + cervical cancer + Daphne Altaica
Antiproliferative activity of different extracts from Daphne altaica
Pall. on selected cancer cells
"The results of this study represent the first evidence that barks
of D. altaica possess effective antiproliferative activities on human cancer
cells. Future phytochemical investigations on this medicinal plant should be
encouraged“.
Pancreatic, lung, liver, breast,
ovarian cancer + more + metastasis + Pau D'Arco
Lapachol: an overview
"Lapachol is a naphthoquinone that was first isolated by E. Paterno
from Tabebuia avellanedae
(Bignoniaceae) in 1882....many others confirmed the efficacy of this naphthoquinone
as an antineoplastic agent. However, in 1974, the National Cancer Institute
concluded that, due to the high concentrations necessary for this drug to act
as an effective chemotherapeutic agent in human cancer which unfortunately also
resulted in very toxic side effects, suspension of further studies on the
action of lapachol as an antineoplastic agent would be terminated. However,
none of these studies considered the effects of lapachol at a molecular level.
This information forms the basis to develop the synthesis of new and novel
lapachol analogues which can be used as the future starting point in future
developments of this potentially potent biological molecule“.
Leukemia +
Thymoquinone rich fraction from Nigella sativa and thymoquinone are
cytotoxic towards colon and leukemic carcinoma cell lines
"In conclusion, this study indicates that TQRF and TQ possess
cytotoxic properties against colorectal cancer and showed more prominent
cytotoxic effects on leukemic cell lines. In spite of TQ, TQRF was also has
potential to be used as anti-cancer treatment. Therefore, TQRF from N. sativa
does have the potential to be developed as a nutraceuticals for preventing the
progression of cancer“.
Breast cancer and Tamoxifen and Fish
Oil
The Impact of Fish Oil on the Chemopreventive Efficacy of Tamoxifen
against Development of N-Methyl-N-Nitrosourea–Induced Rat Mammary
Carcinogenesis
"In this study, we report for the first time that the combination
of a fish oil diet rich in n-3 PUFA and tamoxifen seemed to inhibit
N-methyl-N-nitrosourea–induced mammary carcinogenesis, tumor multiplicity, and
volume to a greater extent than the individual interventions. The potential
superiority of the combination was particularly evident at a suboptimal dose of
tamoxifen, which, by itself, was unable to significantly decrease tumor
development. Because activation of PPARγ is known to inhibit oxidative stress, we examined
the effects of our interventions on circulating and tumor levels of
glutathione, a major intracellular antioxidant. Our results indicate that
reduction in the level of oxidative stress may be a potential mechanism by
which the n-3 PUFA–rich diet potentiated the tumor-suppressive effect of
tamoxifen. Our interventions were well tolerated without evidence of toxicity.
Combined administration of tamoxifen and n-3 PUFA is a promising new approach
to breast cancer prevention. Because of its safety, this combination can
quickly be translated to the clinic if its superiority can be supported by
future studies“.
Skin cancer and Resveratrol
Synergistic Effects of Combined Phytochemicals and Skin Cancer
Prevention in SENCAR Mice
" In conclusion, all combinations showed either additive or
synergistic effects and their joint actions allowed for decreasing the doses of
the compounds. Especially, resveratrol combinations with ellagic acid, grape
seed extract, and other phytochemicals are very potent inhibitors of skin
tumorgenesis, based on the suppression of epidermal hyperplasia as well as on
the modulation of intermediate biomarkers of cell proliferation, cell survival,
inflammation, oncogene mutation, and apoptosis“.
Resveratrol is an antioxidant that is commonly found in many plants. Red
wine, peanuts, grapes and blueberries are some of its rich and popular sources.
Skin cancer + foods containing alkaloids
(caffeine), EGEC (green tea), flavanols (cocoa), genistein (soybean),
Pycnogenol and more
Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility
of Effects and Mechanisms
"Various phytochemicals protect plants and animals against the
damaging effects of UV radiation. They all invoke multiple protective mechanisms,
in many ways representing a critical feature in the efforts to develop
protective strategies against a carcinogen that exerts multiple damaging
effects. The use of agents based on some of the phytochemicals that were
discussed here and the identification of new and more potent analogues, in
addition to common sunscreens, are areas of development that have the potential
to reduce the risk of skin cancer“.
Chemoprevention + foods containing
curcumin (turmeric)
EGCG (green tea), resveratrol (red wine), genistein (soy) and
isothiocyanates(cabbage family)
Dietary Cancer Chemopreventive Agents – Targeting Inflammation and Nrf2
Signaling Pathway
dietary vegetables and fruits have been regarded as rich sources of
chemopreventive agents.
Food phytochemicals such as curcumin, EGCG, resveratrol, genistein and
isothiocyanates, with strong anti-inflammatory activity, have been shown to
inhibit carcinogenesis in preclinical animal models. Epidemiological studies
have clearly documented that the frequent consumption of a diet high in fruits
and vegetables has been linked to a lower risk of many types of cancers
including prostate, colon, oral cavity, stomach, lung and esophagus"
Chemoprevention + foods
containing-sulforaphane (cabbage), lycopene (tomatoes), curcumin
(turmeric), EBCG (green tea) Diallyl sulfide (garlic), Resveratrol (red grapes)
and more
Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling
Involved in the Induction of Cytoprotective Genes by Some Chemopreventive
Phytochemicals
"The activation of Nrf2-ARE signaling by dietary inducers will
fortify cellular defense against oxidative, electrophilic and inflammatory
stresses which are broadly implicated in multi-stage carcinogenesis"
Colorectal cancer + Fresh Ginseng
Effects of Triterpenoid Glycosides from Fresh Ginseng
"AGBE and ginsenosides Rb3, Re, and Rg3 possessed significant antiproliferative
effects and induced changes of morphological appearance on SW480 cells. The
mechanisms of the antiproliferation of AGBE and tested ginsenosides involved
could be cell cycle arrest and induction of apoptosis“.
Cancer general + Dysosma versipellis
Antiproliferation and cell apoptosis inducing bioactivities of
constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines
"This study suggests that most of the compounds from the roots of D.
versipellis could inhibit the growth of human carcinoma cells. In addition, PTO
and DDPT could induce apoptosis of tumor cells“.
Bladder cancer + Antrodia camphorate
Antrodia camphorata extract induces replicative senescence in
superficial TCC, and inhibits the absolute migration capability in invasive
bladder carcinoma cells
"We conclude that ACCE can be rather effective and beneficial in
suppression of both the superficial cancer cell line RT4 and the metastatic
cell lines (TSGH-8301 and T24) through different mechanisms"
Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle
Regulation in Human Colorectal Carcinoma Cells by
4,7-Dimethoxy-5-Methyl-l,3-Benzodioxole Isolated from the Fruiting Body of Antrodia
camphorate
"These findings demonstrate for the first time that SY-1 inhibits
human colon cancer cell proliferation through inhibition of cell growth and
anchorage-independent colony formation in soft agar. However, the detailed
mechanisms of these processes remain unclear and will require further
investigation“.
Metastases + Liver cancer + Sea
Cucumber
Ds-echinoside A, a new triterpene glycoside derived from sea cucumber,
exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF
expressions
"In conclusion, the present study provides evidence that DSEA
possesses marked anti-metastatic activity. We have shown that DSEA plays a role
in the inhibition of Hep G2 cell migration, invasion, and angiogenesis through
suppression of VEGF and MMP-9 and enhancement of TIMP-1 protein expression by
blocking the NF-κB
signaling pathway“.
Cancer Prevention + Spices
Potential of Spice-Derived Phytochemicals for Cancer Prevention
List of spices:
Allspice, Almond meal,
Amechur ground, Anise seed, Anatto ground, Arrowroot powder, Asafoetida,
Basilicum, Bay leaves, Black Pepper, Caraway, Cardamon, Celery, Chili,
Cinnamon, Cit-ac, Cloves, Coriander, Coconut, Cream of Tartar, Cubeba, Cumin,
Dill, Celery, Fennel, Fenugreek, Garlic, Ginger, Grapefruit peel, Honey,
Horseradish, Juniper, Lemon peel, Nutmeg, Nigella, Onion, Orange peel, Poppy
seeds, Saffron, Sugar (brown/Demarara; Maple), Tamarind, Tangerine peel,
Tumric, Vanilla, Wasabi,
Basil, Bay leaves, Cacao, Celery,
Chives, Cardamon, Cayenne, Curry, Dill, Fenugreek, Jalapeno, Kaffir lime,
Lavender, Lemon grass, Marjoran, Mustard, Oregano, Paprika, Parsley, Rose
petals, Rosemary, Sage, Savory, Tarragon, Thyme,
"From the list provided above it is clear that spice-derived
phytochemicals have an enormous potential in the prevention and treatment of
cancer. They can induce apoptosis, suppress proliferation
of tumor cells, inhibit invasion and angiogenesis, and prevent even bone
loss. These phytochemicals mediate their effects through multiple targets and
yet pharmacologically they are highly safe.
More animal studies and clinical trials are needed to prove the
usefulness of these agents. Safety, inexpensive cost, years of intake by humans
and their efficacy make them ideal agents. It is not surprising to note that
Vasco de Gama tried to look for these spices almost five centuries ago“.
Breast + Pancreatic
cancer + Amoora rohituka and chittagonga
Cytotoxicity Effects of Amoora rohituka and chittagonga on Breast and
Pancreatic Cancer Cells
" For MCF-7 cancer cells, the chittagonga (Pet-Ether and CH2Cl2)
and rohituka (Pet-Ether) extracts induced cytotoxicity; the chittagonga (EtoAC)
and rohituka (MeOH) extracts did not induce cytotoxicity. For HTB126, Panc-1,
Mia-Paca2, and Capan-1 cancer cells, only the chittagonga CH2Cl2 extract showed
a significant cytotoxic effect. The extracts were not cytotoxic to normal
fibroblast Hs68 cells, which may be correlated to the specificity of Amoora
extracts in targeting cancerous cells. Based on these results, further
examination of the potential anticancer properties Amoora species and the
identification of the active ingredients of these extracts is warranted“.
Cancer-related Fatigue + Polarity
Therapy
Polarity Therapy for Cancer-Related Fatigue in Patients With Breast
Cancer Receiving Radiation Therapy: A Randomized Controlled Pilot Study
"The present study supports previous experimental research showing
that PT, a noninvasive and gentle energy therapy, may be effective in controlling
CRF. PT is an integrative medicine energy therapy based on the Ayurvedic
medical system used for thousands of years in India and evidence of its
efficacy could lead to further, potentially fruitful, explorations of this
ancient medical practice and/or of other energy therapies such as HT, TT, and
Reiki“.
Lung cancer + Essential Oils
Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In
Vitro and In Vivo"
"Collectively, these data provide insight into the molecular
mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering
this compound a potential anticancer drug for NSCLC“.
Colorectal cancer + Sulforaphane (in
cruciferous vegetables)
Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and
Retarded Tumor Growth in SCID Mice by Sulforaphane
"Our findings suggest that, in addition to the known effects on
cancer prevention, sulforaphane may have antitumor activity in established
colorectal cancer“.
Sulforaphane (SFN), a potent cancer preventive agent, a dietary
isothiocyanate compound found as a precursor glucosinolate in cruciferous
vegetables (Brussels sprouts/cauliflower/broccoli/cabbage)
Doxorubicin-Induced Cardiotoxicity +
L-Glutamine
Oral Glutamine Protects against Acute Doxorubicin-Induced Cardiotoxicity
of Tumor-Bearing Rats
"The Gln supplementation resulted in lower cardiac lipid
peroxidation and peroxintrite levels and elevated cardiac catalase enzyme
activity and GSH compared with the controls, without affecting those of the
tumors. DOX-induced alterations of the echocardiographic parameters were
significantly reduced in the Gln-supplemented rats. These data indicate that
Gln is able to reduce the oxidative damage of cardiomyocytes that occurs soon
after DOX administration and thus protects the heart of a tumor-bearing host
from DOX-induced cardiomyopathy“.
Breast cancer + Curcumin
Injectable Sustained Release Microparticles of Curcumin: A New Concept
for Cancer Chemoprevention
The current study is the first to report the use of an injectable,
sustained release formulation, which, after a single dose, results in
near-constant systemic concentrations of curcumin for several weeks and a
significant inhibition of tumor growth in an orthotopic mammary tumor model.
Further, the results of the study show that sustained low levels of curcumin
achieved with microparticles may elicit certain antitumor effects not observed
after repeated systemic injections.
Intrathoracic cancers + Radiation + Flaxseed
Dietary flaxseed administered post thoracic radiation treatment improves
survival and mitigates radiation-induced pneumonopathy in mice
Dietary FS given post-XRT mitigates radiation effects by decreasing
pulmonary fibrosis, inflammation, cytokine secretion and lung damage while
enhancing mouse survival. Dietary supplementation of FS may be a useful
adjuvant treatment mitigating adverse effects of radiation in individuals
exposed to inhaled radioisotopes or incidental radiation.
Role of cyclin inhibitor protein p21 in the inhibition of HCT116 human
colon cancer cell proliferation by American ginseng (Panax quinquefolius) and
its constituents
"In conclusion, the current study demonstrates that American
ginseng extract inhibits proliferation and cell cycle progression in HCT116
human colon cancer cells through altered expression of key regulatory proteins,
and these actions appear to be dependent on the interaction of both ginsenoside
and polysaccharide components of ginseng extract"
Prostate cancer + Psidium guajava
The Aqueous Soluble Polyphenolic Fraction of Psidium guajava Leaves
Exhibits Potent Anti-Angiogenesis and Anti-Migration Actions on DU145 Cells
"We conclude that PE potentially possesses a strong anti-prostate
cancer effect. Results suggest that PE can be used as an effective clinical
adjuvant anti-prostate cancer chemopreventive"
Melanoma + Peganum harmala
Harmine activates intrinsic and extrinsic pathways of apoptosis in
B16F-10 melanoma
"TUNEL assay and flow cytometric
analysis also confirmed apoptosis. Furthermore, RT-PCR analysis showed
that harmine induced apoptosis in B16F-10 melanoma cells by up-regulating Bax
and activating Caspase-3, 9 and p53 and down-regulating Bcl-2. Harmine
also up-regulated Caspase-8 and Bid, indicating that harmine affected
both extrinsic and intrinsic pathways of apoptosis. This study also showed
inhibitory effects of harmine on some transcription factors and
pro-inflammatory cytokines that protect cell from apoptosis"
Cancer Remission + Agaricus blazei
Phase I Clinical Study of the Dietary Supplement, Agaricus blazei
Murill, in Cancer Patients in Remission
"This trial supports previous evidence that the ABM product is
generally safe, excluding possible allergic reaction......In Japan, researchers
have demonstrated antioxidant, antimutagenic,
antitumor, cancer inhibitory, cancer preventive and immunoenhancing
effects of Agaricus blazei Murill experimentally"
Quality of Life in cancer Patients +
Viscum
album
Review Article: Influence of Viscum album L (European Mistletoe)
Extracts on Quality of Life in Cancer Patients: A Systematic Review of
Controlled Clinical Studies
"Improvements were mainly in regard to coping, fatigue, sleep,
exhaustion, energy, nausea, vomiting, appetite, depression, anxiety, ability to
work, and emotional and functional well-being in general and, less
consistently, in regard to pain, diarrhea, general performance, and side
effects of conventional treatments. VAEs were well tolerated“.
Cervical cancer + Boerhaavia
diffusa Linn. (Punarnava)
Inhibition of Human Cervical Cancer Cell Growth by Ethanolic Extract of
Boerhaavia diffusa Linn. (Punarnava) Root
"In conclusion, B. diffusa fraction 5 (BDF 5) could inhibit the proliferation
of human cervical cancer cell line, HeLa"
Bladder cancer + Antrodia camphorata
Human urinary bladder cancer T24 cells are susceptible to the Antrodia
camphorata extracts
"In conclusion, ACCE is a good anti-cancer agent, being effective
in inducing phase G2M arrest, acting as an anti-proliferative, and an
anti-metastatic agent against bladder cancer cell T24 cells"
Cancer general + Taiwanofungus
camphoratus
Anticancer Effects of Taiwanofungus camphoratus Extracts, Isolated
Compounds and its Combinational use
"In addition, various compounds have been further purified from
these extracts, such as terpenoids, maleic and succinic acids derivatives,
polysaccharides, and other compounds, and they also showed potent cytotoxicity.
Besides, T. camphoratus not only has cytotoxic effect but also produces
synergistic anticancer effect with trichostatin A, lovastatin, and taxol. It is
concluded that T. camphoratus could be considered as a potential anticancer
agent to make cancer no longer a frightening nightmare. However, clinical
trials of T. camphoratus on human subjects are absent, and the involved
mechanism remains unclear. Hence, further investigations would be required“.
Apoptotic Cell Death and Inhibition of Wnt/β-Catenin Signaling Pathway in Human
Colon Cancer Cells by an Active Fraction (HS7) from Taiwanofungus camphoratus
"These results indicate that Taiwanofungus camphoratus may provide
a benefit as integrative medicine for the treatment of colon cancer“.
Prostate cancer + Curcumin
Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of
apoptosis, metastasis and angiogenesis
Curcumin is the principal curcuminoid of the popular Indian spice
turmeric, which is a member of the ginger family (Zingiberaceae)
"The ability of curcumin to inhibit tumor growth, metastasis and
angiogenesis, and enhance the therapeutic potential of TRAIL suggests that
curcumin alone or in combination with TRAIL can be used for prostate cancer
prevention and/or therapy“.
Ovarian cancer + Calomeria
amaranthoides
Potent cytotoxic effects of Calomeria amaranthoides on ovarian cancers
Calomeria amaranthoides is a common Australian plant
"For the first time both crude plant extract from Calomeria amaranthoides
and EPD have been shown to have potent anti-cancer effects against ovarian
cancer“.
Lung cancer + Polygala senega
Anticancer potentials of root extract of Polygala senega against benzo［a］pyrene-induced
lung cancer in mice
"Chemopreventive potentials of Polygala senega against chemically
induced lung cancer in mice are confirmed“.
Breast cancer + Homeopathy
Cytotoxic effects of ultra-diluted remedies on breast cancer cells
"Study demonstrates that the ultra-diluted natural product remedies
prescribed in the ‘Banerji Protocol’ induce cell cycle delay/arrest with
subsequent apoptosis in breast adenocarcinoma cells. Though the degree of the
antisurvival effect appeared to correlate with the presence of the wild-type
p53 gene, overall susceptibility to the inhibitory effects of the remedies
appeared independent of the functional p53 and estrogen-receptor status of the
breast carcinoma cells. Finally, the preferentially elevated cytotoxic effects
on breast adenocarcinoma cells compared with cells derived from normal mammary
epithelium raises the exciting possibility of a window of therapeutic
opportunity for preferentially eliminating breast cancer cells with minimal
damage to the surrounding normal mammary tissue by using the ultra-diluted
remedies investigated in this report. The findings of this study should
encourage further preclinical and animal investigation of these remedies as
preventive and/or therapeutic treatments for breast cancer"
Adverse Effects of cancer treatments
+ Homeopathy
Homeopathic medicines for adverse effects of cancer treatments
"254 participants demonstrated benefits from calendula ointment in
the prevention of radiotherapy-induced dermatitis, and another with 32
participants demonstrated benefits from Traumeel S
(a complex homeopathic medicine) over placebo as a mouthwash for
chemotherapy-induced stomatitis.
The homeopathic medicines used in all eight studies did not seem to
cause any serious adverse effects or interact with conventional treatment"
Brain Tumour + Homeopathy
Ruta 6 selectively induces cell death in brain cancer cells but
proliferation in normal peripheral blood lymphocytes: A novel treatment for
human brain cancer
Both in vivo and in vitro results showed induction of survival-signaling
pathways in normal lymphocytes and induction of death-signaling pathways in
brain cancer cells. Cancer cell death was initiated by telomere erosion and
completed through mitotic catastrophe events. We propose that Ruta in
combination with Ca3(PO4)2 could be used for effective treatment of brain
cancers, particularly glioma.
Melanoma + Homeopathy
Stimulation of lymphocyte anti-melanoma activity by co-cultured
macrophages activated by complex homeopathic medication (CHM)
"Co-culture of macrophages with lymphocytes in the presence of the
CHM enhanced the anti-cancer performance of lymphocytes against a very
aggressive lineage of melanoma cells. These results suggest that non-toxic
therapies using CHMs are a promising alternative approach to the treatment of
melanomas. In addition, they are attractive combination-therapy candidates,
which may enhance the efficacy of conventional medicines by improving the
immune response against tumor cells
Melanoma + Homeopathy
In vitro and in vivo anticancer properties of a Calcarea carbonica
derivative complex (M8) treatment in a murine melanoma model
"We found that M8 has at least two functions, acting as both an
inhibitor of cancer cell adhesion and invasion and as a perlecan expression
antagonist, which are strongly correlated with several metastatic, angiogenic
and invasive factors in melanoma tumors....The findings suggest that this
medication is a promising non-toxic therapy candidate by improving the immune
response against tumor cells or even induce direct dormancy in
malignancies".
Liver Cancer + Hepatitis + Coffee +
Green Tea
Effect of Coffee and Green Tea Consumption on the Risk of Liver Cancer:
Cohort Analysis by Hepatitis Virus Infection Status
Compared with almost never drinkers, increased coffee consumption was
associated with a reduced risk of liver cancer in all subjects A similar risk
tendency was observed in those with either or both HCV and HBV infection. In
contrast, no association was observed between green tea consumption and the
risk of liver cancer in all subjects. Our results suggest that coffee
consumption may reduce the risk of liver cancer regardless of HCV and HBV
infection status, whereas green tea may not reduce this risk
Skin Cancer + Black Tea
Tea Intake and Squamous Cell Carcinoma of the Skin: Influence of Type of
Tea Beverages
"Adjusting for brewing time, the association between skin SCC and
hot black tea consumption suggests a significantly lower risk in consumers of
hot tea compared to nonconsumers. Our results show that tea concentration
(strength), brewing time, and beverage temperature have major influences on the
potential protective effects of hot black tea in relation to skin SCC"
Breast cancer + Malaysian tropical
ginger = Alpinia conchigera/= 'lengkuas ranting'/= 'lengkuas kecil'/= 'lengkuas
1'S-1'-Acetoxyeugenol acetate: a new chemotherapeutic natural compound
against MCF-7 human breast cancer cells.
"It was concluded that AEA isolated from the Malaysian tropical
ginger represents a potential chemotherapeutic agent against human breast
cancer cells with higher cytotoxicity potency than its analogue, ACA“.
It is used as a condiment in the northern states of Peninsular Malaysia
and occasionally in traditional medicine in the east coast to treat fungal
infections. In
Liver, Breast, Lung cancer +
Macrothelypteris torresiana = fern
In vitro and in vivo antitumor activity of Macrothelypteris torresiana
and its acute/subacute oral toxicity
"Macrothelypteris torresiana (Gaud.) Ching (Thelypteridaceae) is
widely distributed in the south of
Colorectal cancer + Curcumin +
radiation therapy
Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to γ-Radiation by Targeting Nuclear
Factor-κB–Regulated
Gene Products
Curcumin is the principal curcuminoid of the popular Indian spice
turmeric, which is a member of the ginger family (Zingiberaceae)
"Collectively, our results suggest that curcumin potentiates the
antitumor effects of radiation therapy in colorectal cancer by suppressing NF-κB and NF-κB–regulated gene products, leading
to inhibition of proliferation and angiogenesis"
Cancer general +
Russula lepida o. rosea mushroom = Harte Zinnober-Täubling
First isolation and characterization of a novel lectin with potent
antitumor activity from a Russula mushroom.
"In summary, a lectin with a distinctive N-terminal sequence, sugar
specificity, hemagglutinating activity with relatively high thermostability and
[Cu.sup.2+] -induced enhancement, and potent antiproliferative and antitumor
activities was isolated from R. lepida fruiting bodies. The potent antitumor
activity of RLL is remarkable and hopefully it can be developed into an agent
for cancer therapy. This report represents an addition to the existing list of
mushroom lectins".
Cervical cancer + Angelica
sinensis (Oliv)
A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels
induces the apoptosis of cervical cancer HeLa cells through an intrinsic
apoptotic pathway.
"Our findings provide a novel understanding of the antitumor
mechanism of this polysaccharide from Angelica sinensis and might be helpful in
developing a new antitumor agent"
Metastatic breast cancer + Carvacrol
Anti-proliferative effects of carvacrol on a human metastatic breast
cancer cell line, MDA-MB 231
Carvacrol, (2-methyl-5-(l-methylethyl)-phenol), is a major component of
the essential oils of oregano and thyme
"The data in the present study clearly demonstrated anti-tumor
effects of carvacrol on human metastatic breast cancer cells, MDA-MB 231, and
that the compound could have a potential therapeutic significance in treating
cancer“.
Taste and Smell alterations +
Delta-9-tetrahydrocannabinol (THC)
Delta-9-tetrahydrocannabinol may palliate altered chemosensory
perception in cancer patients: results of a randomized, double-blind,
placebo-controlled pilot trial
Taste and smell (chemosensory) alterations are common and distressing
among advanced cancer patients
Delta-9-tetrahydrocannabinol (THC) is the main psychoactive substance
found in plants of the species Cannabis sativa
"THC may be useful in the palliation of chemosensory alterations
and to improve food enjoyment for cancer patients".
Lung cancer + Ocimum
gratissimum
Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung
Adenocarcinoma Cell A549
"In conclusion, the present study provides evidences that OGE
treatments significantly alter viability of lung adenocarcinoma A549 cells
through a synergy of induction of apoptotic signaling and suppression of
antiapoptotic signaling, as shown in Figure 7. Moreover, OGE treatment
simultaneously inhibits the activation of ERK and enhances the activation of
JNK and p38, which is consistent with the enhanced apoptotic signaling and
reduced antiapoptotic signaling based on their well-known effects on these
signal cascades (Figure 7). By manipulating both arms of apoptotic and
antiapoptotic pathway, OGE represents a promisingly effective chemopreventive
agent against lung adenocarcinoma“.
Advanced/Recurrent
Colorectal Cancer + Peripheral Neurotoxicity Side Effects of Oxaliplatin +
Goshajinkigan
Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in
Patients with Advanced or Recurrent Colorectal Cancer
Kampō (or Kanpō) medicine is the Japanese study and adaptation
of Traditional Chinese medicine.
"Peripheral neurotoxicity is the major limiting factor for
oxaliplatin therapy....
Concomitant administration of GJG reduced the neurotoxicity of
oxaliplatin in patients that received chemotherapy for colorectal cancer".
Various Cancers + Ayurveda
Traditional medicinal plants as anticancer agents from
"Recently, a greater emphasis has been given towards the researches
on complementary and alternative medicine that deals with cancer management.
Plants have long history of use in the
treatment of cancer. Medicinal plants maintain the health and vitality
of individuals, and also cure various diseases, including cancer without
causing toxicity. Plants derived components have played an important role in
the development of several clinically useful anticancer agents. In different
region of Chhattisgarh many traditional healers use various medicinal plants for
treating of various cancer. This review revealed that many of medicinal plants
used by traditional healer are reported to have scientific evidence. There is a
need to explore the plants which are not reported scientifically by in-vitro or
in-vivo screening methods. These plants can provide potential bioactive
compounds for the development of new ‘leads’ to combat cancer diseases"
Breast Cancer + Exercise
Effects of exercise on breast cancer patients and survivors: a
systematic review and meta-analysis
"Exercise is an effective intervention to improve quality of life,
cardiorespiratory fitness, physical functioning and fatigue in breast cancer
patients and survivors...Exercise also led to significant improvements in
physical functioning and peak oxygen consumption and in reducing symptoms of
fatigue... Larger trials that have a greater focus on study quality and adverse
effects and that examine the long-term benefits of exercise are needed for this
patient group“.
Breast Cancer Recurrence + Soy Isoflavones
Effect of soy isoflavones on breast cancer recurrence and death for
patients receiving adjuvant endocrine therapy
"High dietary intake of soy isoflavones was associated with lower
risk of recurrence among post-menopausal patients with breast cancer positive
for estrogen and progesterone receptor and those
who were receiving anastrozole as endocrine therapy“.
Cancer General, Metastasis, Ovarian Cancer,
Melanoma + Ginseng
Chemistry and Cancer Preventing Activities of Ginseng Saponins and Some
Related Triterpenoid Compounds
"Anti-tumor activities are the properties characteristic not only
to Ginseng saponins but also to other pentacyclic triterpenes.It is noteworthy,
however, that ginsenosides, tetracyclic
dammarane-type triterpenoid saponins, could be applied safely due to
their mostly non-toxic and non-hemolytic characteristics. Ginseng has been
employed in Chinese medicine and folklore medicine in the
Liver Cancer + Panax notoginseng
Anti-proliferative effects of raw and steamed extracts of Panax
notoginseng and its ginsenoside constituents on human liver cancer cells
"Steaming increased the concentrations of ginsenoside Rh2, Rk1, Rk3
and 20S-Rg3 and enhanced growth inhibition of liver cancer cells. Conclusion
Steaming changes the chemical profile as well
as anti-cancer biological activities of P. notoginseng. Steamed P.
notoginseng contains potential compounds for the treatment of liver
cancer"
Yoga + Breast Cancer + Fatigue
Yoga for Persistent Fatigue in Breast Cancer Survivors: Results of a
Pilot Study
There was a significant improvement in fatigue scores from pre- to post-intervention
that was maintained at the 3-month post-intervention followup. Significant
improvements were also observed in measures of physical function, depressed
mood, and quality of life. These results support the acceptability of this
intervention and suggest that it may have beneficial effects on persistent
post-treatment fatigue. However, results require replication in a larger
randomized controlled trial.
Homeopathy + Psorinum + Stomach,
Gall Bladder, Pancreatic + Liver Cancers
Psorinum Therapy in Treating Stomach, Gall Bladder, Pancreatic, and
Liver Cancers: A Prospective Clinical Study
The limitation of this study is that it did not have any placebo or
treatment control arm; therefore, it cannot be concluded that Psorinum Therapy
is effective in improving the survival and the quality of life of the
participants due to the academic rigours of the scientific clinical trials.
This study also cannot rule out the effects of the implemented allopathic and
homeopathic supportive measures
in the observed results. However, the results of the study showed a fair
number of complete and partial tumor responses along with impressive survival
outcomes in difficult to treat cancer types. Therefore, randomized double-blind
clinical trial, detailed molecular, pharmacokinetics, and pharmacodynamics
studies should be conducted for further scientific exploration of this
alternative cancer treatment to determine if it can be integrated into the
mainstream oncology.
Protein, Dairy Foods and Cancer
Breast Cancer + metastasis +
Coenzyme Q10
Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell ine as a
breast cancer cellular model
CoQ10 is a natural lipid-soluble
antioxidant.
"The present study highlights the significance of Coenzyme Q10
effect on the cell invasion/metastasis effecter molecules"
Breast + Prostate Cancer +
Strobilanthes crispus
Anticancer activity of a sub-fraction of dichloromethane extract of
Strobilanthes crispus on human breast and prostate cancer cells in vitro
"Leaves are used in folk medicine for their antidiabetic, diuretic,
anticancer and blood pressure lowering properties. Crude extracts of this plant
have been found to be cytotoxic to human cancer cell lines and protective
against chemically-induced hepatocarcinogenesis in rats.....A dichloromethane
sub-fraction of S. crispus displayed potent anticancer activities in vitro that
can be further exploited for the development of a potential therapeutic
anticancer agent“.
Chemopreventive, Cancer general + DNA damage +
Moringa oleifera Lam
Moringa oleifera Lam. leaves prevent Cyclophosphamide-induced
micronucleus and DNA damage in mice
"Moringa species have long been recognized by folk medicine
practitioners as having value in tumor therapy"
"The results show that the extract has anti-genotoxic effects on
CP-induced lesions in mice. The present results eventually lead us to conclude
that ethanolic extract of M.oleifera leaves possess anti-genotoxic
phytoconstituents".
Lymphoma + Cacao (Theobroma cacao L.)
Antitumor activity against murine lymphoma L5178Y model of proteins from
cacao (Theobroma cacao L.) seeds in relation with in vitro antioxidant activity
"This study is the first report on the biological activity of
semifermented-dry cacao protein fractions with their identification, supporting
the traditional use of the plant. The albumin fraction showed antitumor and
free radical scavenging capacity, however both activities were not correlated.
The protein fractions could be considered as source of potential antitumor
peptides".
Cervical cancer + Corydalis
cava
Cytotoxic activity of proteins isolated from extracts of Corydalis cava
tubers in human cervical carcinoma HeLa cells
"The Corydalis sp. tubers are a rich source of many biologically
active substances, with the extensive use in European and Asian folk medicine. They
have analgetic, sedating, narcotic, anti-inflammatory, anti-allergic and
anti-tumour activities"
The cytotoxic effect of studied proteins toward HeLa cell line cells has
been evident and dependent on increasing dose of the protein
Anticachexia (weight loss, anorexia
and weakness) +
Anticachectic effects of the natural herb Coptidis rhizoma and berberine
on mice bearing colon 26/clone 20 adenocarcinoma
".In conclusion, our study showed that C. rhizoma exerts an
anticachectic effect on colon 26/clone 20–transplanted mice and that the effect
is associated with tumor IL-6 production. We also suggest that berberine, its
major component, might play a role in the prevention of cachexia"
Non melanoma skin cancer, oesphageal
+ colon cancer + Berberine (isoquinoline alkaloid present in roots, rhizome +
stem bark of a number of important medicinal plant species
Berberine inhibits growth, induces G1 arrest and apoptosis in human
epidermoid carcinoma A431 cells by regulating Cdki–Cdk-cyclin cascade,
disruption of mitochondrial membrane potential and cleavage of caspase 3 and
PAR
"Berberine possesses a wide range of biochemical and
pharmacological activities, viz. antidiarrheal, antiarrhythmic and antitumor
activities. Coptidis rhizoma, containing abundant berberine, is shown to
inhibit the proliferation of esophageal cancer cells Berberine inhibits
cyclooxygenase-2 transcriptional activity in human colon cancer cells and
preliminary studies have shown that berberine sulfate inhibits tumor promoting
activity of teleocidin in two-stage chemical carcinogenesis on mouse skin"
Breast cancer + Huanglian (Coptidis
rhizoma), a widely used herb in traditional Chinese medicine,
The extract of huanglian, a medicinal herb, induces cell growth arrest and
apoptosis by upregulation of interferon-β and TNF--α in human breast cancer cells
"The data presented here demonstrate that huanglian extract is
highly effective in inhibiting cell proliferation and inducing apoptotic cell
death in MCF-7 breast cancer cells“.
Cancer General, Liver toxicity +
Berberine (isoquinoline alkaloid present in roots, rhizome and stem bark of a
number of important medicinal plants)
Hepatoprotective effects of berberine on carbob tetrachloride-induced
acute hepatotoxicity in rats
"Berberine is an active compound in Coptidis Rhizoma (Huanglian)
with multiple pharmacological activities including antimicrobial, antiviral,
anti-inflammatory, cholesterol-lowering and anticancer effects. The present
study demonstrates that berberine possesses hepatoprotective effects against
CCl4-induced hepatotoxicity and that the effects are both preventive and
curative"
Cancer general + Berries - Berries
contain many known chemopreventive agents such as anthocyanins and
ellagitannins that can be greatly concentrated in freeze-dried berry powders.
Foodstuffs for Preventing Cancer: The Preclinical and Clinical
Development of Berries
"The objective of this approach is to selectively kill specific
types of cancer cells with minimal effects on their normal counterparts. In
contrast, berry powders contain a mixture of compounds
that seem to affect the expression levels of a wide range of
cancer-related genes (to lesser extents than therapeutic agents;), thus
preventing the conversion of premalignant cells to malignancy at doses that
cause minimal or no cytotoxicity. In this regard, berries seem to fulfill the
requirement of an “ideal” chemopreventive agent . The same is undoubtedly true
of many other foodstuffs; for example, a freeze-dried aqueous extract of broccoli
sprouts was effective at dietary levels in inhibiting chemically induced
bladder cancer with no observable toxicity in rats"
Chemopreventative,
Cancer general + Resveratrol (a dietary polyphenol derived from grapes,
berries, peanuts, and other plant sources)
Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to
Clinical Trials
"The anticancer property of resveratrol has been supported by its
ability to inhibit proliferation of a wide variety of human tumor cells in
vitro. These in vitro data have led to numerous preclinical animal studies to
evaluate the potential of this drug for cancer chemoprevention and
chemotherapy. This review provides concise, comprehensive data from preclinical
in vivo studies in various rodent models of human cancers, highlighting the
related mechanisms of action. Bioavailability, pharmacokinetic, and potential
toxicity studies of resveratrol in humans and ongoing interventional clinical
trials are also presented. The conclusion describes directions for future
resveratrol research to establish its activity and utility as a human cancer
preventive and therapeutic drug".
Head + Neck cancers + malodorous
necrotic ulcers (in cancer patients are of major concern as it leads to social
isolation and poor quality of life) + Eucalyptus Essential Oil
Antibacterial essential oils in malodorous cancer patients: Clinical
observations in 30 patients
"All patients experienced complete resolution of the foul smell by
only the 3rd or 4th day of therapy. As a secondary effect we saw that besides
smell reduction the oils had anti-inflammatory
effects on neoplastic ulcers. In some patients ulcers started to heal
and achieved complete re-epithiliazation. The patients experienced great
personal relief upon resolution of their malodorous conditions. Quality of life
improved significantly with the resulting reintroduction of social contact with
friends and relatives“.
Chemoprevention + Cancer general +
tea + curcumin + Resveratrol + Pomegranate, Lycopene + Luteolin + Genisten and
other promising natural agents.
Perspectives for Cancer Prevention with Natural Compounds
"Various epidemiological and preclinical findings and the results
of several early clinical studies convincingly argue for a definitive role of selected
dietary products in the prevention and treatment of cancers. Many of these
agents target multiple signal transduction pathways, which vary widely
depending on cancer origin.....Since drug-associated toxicity remains a
significant barrier for currently available chemotherapeutic and
chemopreventive drugs, using natural compounds (which have better safety
profiles) as adjuvant therapy with current chemotherapeutic agents may help to
mitigate drug-associated toxicities. For example, genistein was found to
sensitize prostate cancer to radiation in animal studiesand a recent clinical
trial suggested that soy isoflavones could prevent radiation-induced bladder
and bowel adverse effects and erectile dysfunction"
Prostate cancer + curcumin. Curcumin
is the principal curcuminoid of the popular Indian spice turmeric, which is a
member of the ginger family (Zingiberaceae)
Chemopreventive potential of curcumin in prostate cancer
"These results are consistent with this compound’s ability to
up-induce pro-apoptotic proteins and to down-regulate the anti-apoptotic
counterparts. Alone or in combination with TRAIL-mediated immunotherapy or
radiotherapy, curcumin is also reported to be a good inducer of prostate cancer
cell death by apoptosis. Curcumin appears thus as a non-toxic alternative for
prostate cancer prevention, treatment or co-treatment“.
Melanoma + capsaicin
(trans-8-methyl-N-vanillyl-6-nonenamide) is one of the major ingredients in red
pepper among the most commonly and frequently used spices in the world
Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via
the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway
"The present study provides novel insights into the molecular
mechanisms of capsaicin. Furthermore, anti-migration of highly metastatic
B16-F10 melanoma cells by capsaicin can be considered an effective approach for
the suppression of cancer invasion and metastasis"
Cancer General + Moringa
oleifera Lam
Moringa oleifera Lam. leaves prevent Cyclophosphamide-induced
micronucleus and DNA damage in mice
"Leaves of M. oleifera contain rich amount of antioxidants. It is
reported that M.oleifera has 46 antioxidants and 36 anti-inflammatory compounds
naturally occurring in it. A possible explanation for the protective effect
recorded in the present investigation could be the involvement of its
antioxidant and scavenging properties. Antioxidants provide protection by
scavenging reactive oxidative species (ROS) that damage DNA and initiate diseases
such as cancer. Ethanolic extract of M.olerifera leaves have been reported to
contain tannins, saponins, flavonoids, glycosides and terpenoids. Antioxidant
vitamins, flavonoids, glucosinolates and organo-sulfur compounds have been
proven to have antimutagenic or anticarcinogenic potential“.
Vorwort/Suchen Zeichen/Abkürzungen Impressum